Phenotypes associated with this allele

• Allele Symbol: Hoxa2^tm1.1Fmr
• Allele Name: targeted mutation 1.1, Filippo M Rijli
• Allele ID: MGI:2385690
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxa2^tm1.1Fmr/Hoxa2^tm1.1Fmr	involves: 129/Sv * C57BL/6 * SJL	MGI:3773537
cn2	Hoxa2^tm1.1Fmr/Hoxa2^tm1.1Fmr Tg(CAG-cre/ERT2)F34Fmr/0	involves: 129 * CD-1	MGI:5470404
cn3	Hoxa2^tm1.1Fmr/Hoxa2^tm1.1Fmr H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:5491198
cn4	Hoxa2^tm1Ipc/Hoxa2^tm1.1Fmr Tg(CAG-cre/ERT2)F34Fmr/0	involves: 129/Sv * 129S2/SvPas * C57BL/6 * CD-1	MGI:4415144
cn5	Hoxa2^tm1.1Fmr/Hoxa2^tm1.1Fmr Tg(CAG-cre/ERT2)F34Fmr/0	involves: 129/Sv * C57BL/6 * CD-1	MGI:4415142
cn6	Hoxa2^tm1.1Fmr/Hoxa2^tm1.1Fmr H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129/Sv * C57BL/6J * CBA/J	MGI:4415143
cx7	Hoxa2^tm1.1Fmr/Hoxa2^tm1.1Fmr Tg(CAG-cre/ERT2)F34Fmr/0	involves: 129/Sv * C57BL/6 * CD-1	MGI:4415140

Genotype
MGI:3773537

hm1

• Allelic Composition: Hoxa2^tm1.1Fmr/Hoxa2^tm1.1Fmr
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:75130 , J:80131 )

• mice exhibit no obvious defects including normal fertility and lifespan (J:75130)

Genotype
MGI:5470404

cn2

• Allelic Composition: Hoxa2^tm1.1Fmr/Hoxa2^tm1.1Fmr; Tg(CAG-cre/ERT2)F34Fmr/0
• Genetic Background: involves: 129 * CD-1

nervous system

abnormal brain development ( J:193058 )

• increased oligodendrogenesis in the prepontine (rhombomere 2- and 3-derived) and pontine territories (rhombomere 4-derived) at E13.5 5 in mice exposed to tamoxifen at E10.5

increased oligodendrocyte progenitor number ( J:193058 )

• in the basal plate of rhombomere 3-derived and pontine territory (rhombomere 4-d) at E13.5 in mice exposed to tamoxifen at E10.5 due to increased proliferation in the ventricular zone

• in the prepontine (rhombomere 2- and 3-derived) territory at E13.5 in mice exposed to tamoxifen at E10.5

cellular

increased oligodendrocyte progenitor number ( J:193058 )

• in the basal plate of rhombomere 3-derived and pontine territory (rhombomere 4-d) at E13.5 in mice exposed to tamoxifen at E10.5 due to increased proliferation in the ventricular zone

• in the prepontine (rhombomere 2- and 3-derived) territory at E13.5 in mice exposed to tamoxifen at E10.5

Genotype
MGI:5491198

cn3

• Allelic Composition: Hoxa2^tm1.1Fmr/Hoxa2^tm1.1Fmr; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

mortality/aging

lethality throughout fetal growth and development ( J:197162 )

nervous system

abnormal cochlear VIII nucleus morphology ( J:197162 )

Genotype
MGI:4415144

cn4

• Allelic Composition: Hoxa2^tm1Ipc/Hoxa2^tm1.1Fmr; Tg(CAG-cre/ERT2)F34Fmr/0
• Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * CD-1

craniofacial

abnormal craniofacial bone morphology ( J:102845 )

• when tamoxifen is administered beginning at E11.5 or E12.5, mice exhibit similar craniofacial defects as observed in Hoxa2^tm1.1Fmr Tg(CAG-cre/ERT2)F34Fmr homozygotes

small ears ( J:102845 )

• when tamoxifen is administered beginning at E12.5 or E13.5

hearing/vestibular/ear

small ears ( J:102845 )

• when tamoxifen is administered beginning at E12.5 or E13.5

skeleton

abnormal craniofacial bone morphology ( J:102845 )

• when tamoxifen is administered beginning at E11.5 or E12.5, mice exhibit similar craniofacial defects as observed in Hoxa2^tm1.1Fmr Tg(CAG-cre/ERT2)F34Fmr homozygotes

growth/size/body

small ears ( J:102845 )

• when tamoxifen is administered beginning at E12.5 or E13.5

Genotype
MGI:4415142

cn5

• Allelic Composition: Hoxa2^tm1.1Fmr/Hoxa2^tm1.1Fmr; Tg(CAG-cre/ERT2)F34Fmr/0
• Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

mortality/aging

perinatal lethality, complete penetrance ( J:102845 )

• when tamoxifen is administered beginning at E7.0

craniofacial

abnormal craniofacial bone morphology ( J:102845 )

• when tamoxifen is administered beginning at E7.0 or E9.5, second arch structures are replaced with a mirror duplication of first arch structures

• when tamoxifen is administered beginning at E11.5, second arch cartilaginous derivatives are abnormal

• when tamoxifen is administered beginning at E12.5, second arch skeletal elements are only mildly affected

abnormal styloid process morphology ( J:102845 )

• when tamoxifen is administered beginning at E11.5, the styloid process is malformed and associated with ectopic cartilage

absent hyoid bone lesser horns ( J:102845 )

• when tamoxifen is administered beginning at E9.5, E10.5, E11.0 or E11.5, mice lack the lesser horns of the hyoid bone

abnormal gonial bone morphology ( J:102845 )

• when tamoxifen is administered beginning at E7.0, the gonial bone appears transformed such that it is enlarged and stretches across, bridging over the two halves of the mirror duplication

• when tamoxifen is administered beginning at E8.0, gonial bone phenotype is variable, ranging from a malformed gonial bone to complete transformation

• however, the gonial bone is normal when mice are treated with tamoxifen beginning at E9.5 or later

abnormal stapes morphology ( J:102845 )

• when tamoxifen is administered beginning at E11.5, the stapes is malformed and associated with ectopic cartilage

absent outer ear ( J:102845 )

• when tamoxifen is administered beginning up to E11.5

hearing/vestibular/ear

absent outer ear ( J:102845 )

• when tamoxifen is administered beginning up to E11.5

abnormal middle ear morphology ( J:102845 )

• when tamoxifen is administered beginning at E9.5, E10.5, or E11.5, middle ear elements are duplicated, with the exception of the gonial bone

abnormal gonial bone morphology ( J:102845 )

• when tamoxifen is administered beginning at E7.0, the gonial bone appears transformed such that it is enlarged and stretches across, bridging over the two halves of the mirror duplication

• when tamoxifen is administered beginning at E8.0, gonial bone phenotype is variable, ranging from a malformed gonial bone to complete transformation

• however, the gonial bone is normal when mice are treated with tamoxifen beginning at E9.5 or later

abnormal stapes morphology ( J:102845 )

• when tamoxifen is administered beginning at E11.5, the stapes is malformed and associated with ectopic cartilage

skeleton

abnormal craniofacial bone morphology ( J:102845 )

• when tamoxifen is administered beginning at E7.0 or E9.5, second arch structures are replaced with a mirror duplication of first arch structures

• when tamoxifen is administered beginning at E11.5, second arch cartilaginous derivatives are abnormal

• when tamoxifen is administered beginning at E12.5, second arch skeletal elements are only mildly affected

abnormal styloid process morphology ( J:102845 )

• when tamoxifen is administered beginning at E11.5, the styloid process is malformed and associated with ectopic cartilage

absent hyoid bone lesser horns ( J:102845 )

• when tamoxifen is administered beginning at E9.5, E10.5, E11.0 or E11.5, mice lack the lesser horns of the hyoid bone

abnormal gonial bone morphology ( J:102845 )

• when tamoxifen is administered beginning at E7.0, the gonial bone appears transformed such that it is enlarged and stretches across, bridging over the two halves of the mirror duplication

• when tamoxifen is administered beginning at E8.0, gonial bone phenotype is variable, ranging from a malformed gonial bone to complete transformation

• however, the gonial bone is normal when mice are treated with tamoxifen beginning at E9.5 or later

abnormal stapes morphology ( J:102845 )

• when tamoxifen is administered beginning at E11.5, the stapes is malformed and associated with ectopic cartilage

growth/size/body

absent outer ear ( J:102845 )

• when tamoxifen is administered beginning up to E11.5

Genotype
MGI:4415143

cn6

• Allelic Composition: Hoxa2^tm1.1Fmr/Hoxa2^tm1.1Fmr; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

craniofacial

abnormal craniofacial bone morphology ( J:102845 )

• structures derived from the second arch, including the stapes, styloid process, and lesser horns of the hyoid bone, are absent and replaced by first arch-like derived structures, including duplicated incus, malleus, and tympanic bone, transformed gonial bone, and partially duplicated Meckel's cartilage, with reverse polarity

absent styloid process ( J:102845 )

abnormal Meckel's cartilage morphology ( J:102845 )

• partially duplicated

abnormal hyoid bone morphology ( J:102845 )

• the lesser horns of the hyoid bone are absent

abnormal incus morphology ( J:102845 )

• duplicated

abnormal malleus morphology ( J:102845 )

abnormal gonial bone morphology ( J:102845 )

• the gonial bone appears transformed such that it is enlarged and stretches across, bridging over the two halves of the mirror duplication

absent stapes ( J:102845 )

absent outer ear ( J:102845 )

hearing/vestibular/ear

abnormal incus morphology ( J:102845 )

• duplicated

abnormal malleus morphology ( J:102845 )

abnormal gonial bone morphology ( J:102845 )

• the gonial bone appears transformed such that it is enlarged and stretches across, bridging over the two halves of the mirror duplication

absent stapes ( J:102845 )

absent outer ear ( J:102845 )

duplicated tympanic ring ( J:102845 )

• duplicated tympanic bone

skeleton

abnormal craniofacial bone morphology ( J:102845 )

• structures derived from the second arch, including the stapes, styloid process, and lesser horns of the hyoid bone, are absent and replaced by first arch-like derived structures, including duplicated incus, malleus, and tympanic bone, transformed gonial bone, and partially duplicated Meckel's cartilage, with reverse polarity

absent styloid process ( J:102845 )

abnormal Meckel's cartilage morphology ( J:102845 )

• partially duplicated

abnormal hyoid bone morphology ( J:102845 )

• the lesser horns of the hyoid bone are absent

abnormal incus morphology ( J:102845 )

• duplicated

abnormal malleus morphology ( J:102845 )

abnormal gonial bone morphology ( J:102845 )

• the gonial bone appears transformed such that it is enlarged and stretches across, bridging over the two halves of the mirror duplication

absent stapes ( J:102845 )

growth/size/body

absent outer ear ( J:102845 )

Genotype
MGI:4415140

cx7

• Allelic Composition: Hoxa2^tm1.1Fmr/Hoxa2^tm1.1Fmr; Tg(CAG-cre/ERT2)F34Fmr/0
• Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

normal phenotype

no abnormal phenotype detected ( J:102845 )

• newborn mice are normal