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Allele Symbol Allele Name Allele ID |
Hoxa2tm1(tetO)Mllo targeted mutation 1, Moises Mallo MGI:2385709 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• segmentation and patterning of rhombomere 2 and 3 are disrupted as determined by marker expression patterns
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• segmentation and patterning of rhombomere 2 and 3 are disrupted as determined by marker expression patterns
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die within 24 hours of birth
• however, mice feed and appear normal at 4 hours after birth
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• the lesser horn of the hyoid bone is smaller or absent compared to in wild-type mice
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• despite middle ear abnormalities mice do not exhibit any duplications in middle ear structures as observed in other Hoxa2 null mice
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• the malleus shows an underdevelopment of the processus brevis
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• the stapes shape is abnormal without arch and the stapes does not articulate with the incus
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• the stapes does not articulate with the incus
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• tongue and hyoid musculature exhibit abnormal insertion
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• mice exhibit a cleft in the posterior portion of the tongue
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• tongue and hyoid musculature exhibit abnormal insertion
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| N |
• mice exhibit normal hindbrain organization
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| N |
• mice exhibit normal external ear morphology
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• despite middle ear abnormalities mice do not exhibit any duplications in middle ear structures as observed in other Hoxa2 null mice
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• the malleus shows an underdevelopment of the processus brevis
|
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• the stapes shape is abnormal without arch and the stapes does not articulate with the incus
|
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• the lesser horn of the hyoid bone is smaller or absent compared to in wild-type mice
|
|
• despite middle ear abnormalities mice do not exhibit any duplications in middle ear structures as observed in other Hoxa2 null mice
|
|
• the malleus shows an underdevelopment of the processus brevis
|
|
• the stapes shape is abnormal without arch and the stapes does not articulate with the incus
|
|
• tongue and hyoid musculature exhibit abnormal insertion
|
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• mice exhibit a cleft in the posterior portion of the tongue
|
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• tongue and hyoid musculature exhibit abnormal insertion
|
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• mice exhibit a cleft in the posterior portion of the tongue
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the stapedial artery is displaced rostrally compared to in wild-type mice
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• the oval window of the otic capsule is absent
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• mice exhibit extra cartilage structures in the middle ear
• however, the gonial bone is normal
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• while the shape of the malleus is normal it remains attached via a small bridge to the extra cartilage found in the middle ear
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• the morphology of the tympanic ring is shorter than in wild-type mice and exhibits a small membranous element close to the distal end
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• the oval window of the otic capsule is absent
|
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• the lesser horn of the hyoid bone is smaller or absent compared to in wild-type mice
|
|
• mice exhibit extra cartilage structures in the middle ear
• however, the gonial bone is normal
|
|
• while the shape of the malleus is normal it remains attached via a small bridge to the extra cartilage found in the middle ear
|
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• some mice exhibit a cleft palate
|
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• tongue and hyoid musculature exhibit abnormal insertion
|
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• some mice exhibit a cleft palate
|
|
• tongue and hyoid musculature exhibit abnormal insertion
|
|
• the stapedial artery is displaced rostrally compared to in wild-type mice
|
|
• tongue and hyoid musculature exhibit abnormal insertion
|
| N |
• mice exhibit normal hindbrain organization
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• only one mouse exhibited abnormal contributions of r4 neurons to the facial nerve
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• the oval window of the otic capsule is absent
|
|
• the lesser horn of the hyoid bone is smaller or absent compared to in wild-type mice
|
|
• mice exhibit extra cartilage structures in the middle ear
• however, the gonial bone is normal
|
|
• while the shape of the malleus is normal it remains attached via a small bridge to the extra cartilage found in the middle ear
|
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• some mice exhibit a cleft palate
|
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• tongue and hyoid musculature exhibit abnormal insertion
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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