Phenotypes associated with this allele

• Allele Symbol: Hoxa2^tm2.1Fmr
• Allele Name: targeted mutation 2.1, Filippo M Rijli
• Allele ID: MGI:2385712
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxa2^tm2.1Fmr/Hoxa2^tm2.1Fmr	involves: 129S2/SvPas	MGI:5470403
hm2	Hoxa2^tm2.1Fmr/Hoxa2^tm2.1Fmr	involves: 129S2/SvPas * C57BL/6	MGI:5491199
hm3	Hoxa2^tm2.1Fmr/Hoxa2^tm2.1Fmr	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:3773624
cx4	Hoxa2^tm2.1Fmr/Hoxa2^tm2.1Fmr Hoxb2^tm2.2Fmr/Hoxb2^tm2.2Fmr	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:5470407

Genotype
MGI:5470403

hm1

• Allelic Composition: Hoxa2^tm2.1Fmr/Hoxa2^tm2.1Fmr
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain development ( J:193058 )

• increased oligodendrogenesis in the prepontine territory (rhombomere 2- and 3-derived) at E13.5

• however, migration of oligodendrite progenitor cells is normal

increased oligodendrocyte progenitor number ( J:193058 )

• in the prepontine territory (rhombomere 2- and 3-derived) at E13.5 due to increased proliferation

• however, oligodendrocyte progenitor cell and mature oligodendrocyte numbers are normal at E18.5

cellular

increased oligodendrocyte progenitor number ( J:193058 )

• in the prepontine territory (rhombomere 2- and 3-derived) at E13.5 due to increased proliferation

• however, oligodendrocyte progenitor cell and mature oligodendrocyte numbers are normal at E18.5

Genotype
MGI:5491199

hm2

• Allelic Composition: Hoxa2^tm2.1Fmr/Hoxa2^tm2.1Fmr
• Genetic Background: involves: 129S2/SvPas * C57BL/6

nervous system

nervous system phenotype ( J:197162 )

N • no reduction in ventral nucleus of the lateral lemniscus is observed at E18.5

N • the medial olivocochlear (MOC) bundle forms normally

Genotype
MGI:3773624

hm3

• Allelic Composition: Hoxa2^tm2.1Fmr/Hoxa2^tm2.1Fmr
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

mortality/aging

neonatal lethality, complete penetrance ( J:75129 )

• mice die within 24 hours of birth

behavior/neurological

abnormal behavior ( J:75129 )

• authors state that mice exhibit identical phenotype as other Hoxa2 null mice

craniofacial

abnormal craniofacial morphology ( J:75129 )

• authors state that mice exhibit identical phenotype as other Hoxa2 null mice

hearing/vestibular/ear

abnormal ear morphology ( J:75129 )

• authors state that mice exhibit identical phenotype as other Hoxa2 null mice

nervous system

abnormal nervous system morphology ( J:75129 )

• authors state that mice exhibit identical phenotype as other Hoxa2 null mice

skeleton

abnormal skeleton morphology ( J:75129 )

• authors state that mice exhibit identical phenotype as other Hoxa2 null mice

Genotype
MGI:5470407

cx4

• Allelic Composition: Hoxa2^tm2.1Fmr/Hoxa2^tm2.1Fmr; Hoxb2^tm2.2Fmr/Hoxb2^tm2.2Fmr
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

nervous system

abnormal brain development ( J:193058 )

• increased oligodendrogenesis in the rhombomere 2-derived, but not rhombomere 3-derived, territory at E13.5

• reduced oligodendrogenesis in the pontine territory (rhombomere 4-derived) at E13.5

decreased oligodendrocyte progenitor number ( J:193058 )

• in pontine territory (rhombomere 4-derived) at E13.5 due to reduced proliferation

increased oligodendrocyte progenitor number ( J:193058 )

• in rhombomere 2-derived, but not rhombomere 3-derived, territory at E13.5 due to increased proliferation

cellular

decreased oligodendrocyte progenitor number ( J:193058 )

• in pontine territory (rhombomere 4-derived) at E13.5 due to reduced proliferation

increased oligodendrocyte progenitor number ( J:193058 )

• in rhombomere 2-derived, but not rhombomere 3-derived, territory at E13.5 due to increased proliferation