About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lhx1tm2.1Bhr
targeted mutation 2.1, Richard R Behringer
MGI:2385716
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
En1tm2(cre)Wrst/En1+
Lhx1tm2.1Bhr/Lhx1tm2.1Bhr
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:3719688
cn2
En1tm2(cre)Wrst/En1+
Lhx1tm1Tmj/Lhx1tm2.1Bhr
Lhx5tm1Lmgd/Lhx5tm1Lmgd
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:3719690
cn3
Lhx1tm1Tmj/Lhx1tm2.1Bhr
Tg(Pax2-cre)10Shwl/0
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CD-1 * SJL MGI:3615499
cn4
Lhx1tm2.1Bhr/Lhx1tm1Tmj
Tg(Hoxb7-cre)13Amc/0
involves: 129S/SvEv * C57BL/6 MGI:3580500
cn5
Lhx1tm2.1Bhr/Lhx1tm1Tmj
Tg(Rarb-cre)1Bhr/0
involves: 129S/SvEv * C57BL/6 * SJL MGI:3580503


Genotype
MGI:3719688
cn1
Allelic
Composition
En1tm2(cre)Wrst/En1+
Lhx1tm2.1Bhr/Lhx1tm2.1Bhr
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm2(cre)Wrst mutation (1 available); any En1 mutation (34 available)
Lhx1tm2.1Bhr mutation (0 available); any Lhx1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable and fertile




Genotype
MGI:3719690
cn2
Allelic
Composition
En1tm2(cre)Wrst/En1+
Lhx1tm1Tmj/Lhx1tm2.1Bhr
Lhx5tm1Lmgd/Lhx5tm1Lmgd
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm2(cre)Wrst mutation (1 available); any En1 mutation (34 available)
Lhx1tm1Tmj mutation (0 available); any Lhx1 mutation (22 available)
Lhx1tm2.1Bhr mutation (0 available); any Lhx1 mutation (22 available)
Lhx5tm1Lmgd mutation (0 available); any Lhx5 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• largely absent at E18.5
• layer is absent at E18.5
• however, the external granule cell layer appears normal
• small at E18.5 compared to controls




Genotype
MGI:3615499
cn3
Allelic
Composition
Lhx1tm1Tmj/Lhx1tm2.1Bhr
Tg(Pax2-cre)10Shwl/0
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1tm1Tmj mutation (0 available); any Lhx1 mutation (22 available)
Lhx1tm2.1Bhr mutation (0 available); any Lhx1 mutation (22 available)
Tg(Pax2-cre)10Shwl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

renal/urinary system
• kidneys are rudimentary in dead neonates
• some dead neonates have hydronephrotic kidneys
• at E14.5, kidneys are approximately half the size of wild-type kidneys
• at 3 weeks, mice displayed renal hypoplasia or renal hypoplasia with unilateral hydronephrosis and megaureter
• 2 of 7 neonates necropsied on P1 had duplex kidneys
• at E14.5, 20% of mutants have unilateral renal agenesis
• the two ureters from the duplex kidneys join before entering bladder
• in some instances, the ureter and bladder do not separate or attach to the bladder
• the ureter is very tortuous
• at E11.5, ureteric bud is Y-shaped not T-shaped suggesting branching is impaired
• at E12.4, reduced branching is observed in the ureteric bud
• at E11.5, ureteric bud outgrowth is delayed

embryo
• only rostral-most part of duct forms in mutants
• female sex ducts are rudimentary
• at E10.75, extension of the nephric duct to urogenital sinus is impaired
• at E14.5, nephric duct is not maintained
• male sex ducts are rudimentary
• at E10.75, extension of the nephric duct to urogenital sinus is impaired




Genotype
MGI:3580500
cn4
Allelic
Composition
Lhx1tm2.1Bhr/Lhx1tm1Tmj
Tg(Hoxb7-cre)13Amc/0
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1tm1Tmj mutation (0 available); any Lhx1 mutation (22 available)
Lhx1tm2.1Bhr mutation (0 available); any Lhx1 mutation (22 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• hypoplastic metanephroi with reduced number of glomeruli
• however, morphologically normal medulla and glomeruli
• neonates had small metanephroi that were functional at birth
• observed in 40% of mutants
• greatly reduced numbers of developing nephrons at birth
• the distal ureter was closed in both sexes
• the distal ureter ended abnormally in the uterus in some females
• observed in 40% of mutants
• delayed induction of the ureteric bud

reproductive system
• 57.1% of mutant females had completely or partially absent uteri with residual uterine tissue discontinuously present
• posterior uterus was more frequently absent compared to the anterior region
• 57.1% of mutant females had completely or partially absent uteri
• absent epididymis in all mutant males

embryo
• loss of caudal mesonephric tubules; however, the cranial mesonephros was present
• exhibited Mullerian duct aplasia, impaired posterior elongation of the Mullerian duct and Mullerian duct degeneration adjacent to where the Wolffian duct was lost
• degeneration of the nephric (Wolffian) duct epithelium that resulted in the absence of most parts of the reproductive tract in all mutant males, except for some residual tissue




Genotype
MGI:3580503
cn5
Allelic
Composition
Lhx1tm2.1Bhr/Lhx1tm1Tmj
Tg(Rarb-cre)1Bhr/0
Genetic
Background
involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1tm1Tmj mutation (0 available); any Lhx1 mutation (22 available)
Lhx1tm2.1Bhr mutation (0 available); any Lhx1 mutation (22 available)
Tg(Rarb-cre)1Bhr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• died within the first day of birth

renal/urinary system
• absent glomeruli and their associated tubules in neonates
• nephron development was arrested at the stage of the renal vesicle
• medulla was not correctly formed in neonates
• neonates had small metanephroi without nephrons but with normal ureters and normal reproductive tracts
• neonates had small metanephroi with no nephrons
• shrunken bladder with no urine





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory