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Allele Symbol Allele Name Allele ID |
Lhx1tm2.1Bhr targeted mutation 2.1, Richard R Behringer MGI:2385716 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• largely absent at E18.5
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• layer is absent at E18.5
• however, the external granule cell layer appears normal
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• small at E18.5 compared to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• kidneys are rudimentary in dead neonates
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• some dead neonates have hydronephrotic kidneys
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• at E14.5, kidneys are approximately half the size of wild-type kidneys
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• at 3 weeks, mice displayed renal hypoplasia or renal hypoplasia with unilateral hydronephrosis and megaureter
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• 2 of 7 neonates necropsied on P1 had duplex kidneys
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• at E14.5, 20% of mutants have unilateral renal agenesis
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• the two ureters from the duplex kidneys join before entering bladder
• in some instances, the ureter and bladder do not separate or attach to the bladder
• the ureter is very tortuous
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• at E11.5, ureteric bud is Y-shaped not T-shaped suggesting branching is impaired
• at E12.4, reduced branching is observed in the ureteric bud
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• at E11.5, ureteric bud outgrowth is delayed
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• only rostral-most part of duct forms in mutants
• female sex ducts are rudimentary
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• at E10.75, extension of the nephric duct to urogenital sinus is impaired
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• at E14.5, nephric duct is not maintained
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• male sex ducts are rudimentary
• at E10.75, extension of the nephric duct to urogenital sinus is impaired
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hypoplastic metanephroi with reduced number of glomeruli
• however, morphologically normal medulla and glomeruli
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• neonates had small metanephroi that were functional at birth
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• observed in 40% of mutants
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• greatly reduced numbers of developing nephrons at birth
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• the distal ureter was closed in both sexes
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• the distal ureter ended abnormally in the uterus in some females
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• observed in 40% of mutants
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• delayed induction of the ureteric bud
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• 57.1% of mutant females had completely or partially absent uteri with residual uterine tissue discontinuously present
• posterior uterus was more frequently absent compared to the anterior region
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• 57.1% of mutant females had completely or partially absent uteri
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• absent epididymis in all mutant males
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• loss of caudal mesonephric tubules; however, the cranial mesonephros was present
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• exhibited Mullerian duct aplasia, impaired posterior elongation of the Mullerian duct and Mullerian duct degeneration adjacent to where the Wolffian duct was lost
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• degeneration of the nephric (Wolffian) duct epithelium that resulted in the absence of most parts of the reproductive tract in all mutant males, except for some residual tissue
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• died within the first day of birth
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• absent glomeruli and their associated tubules in neonates
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• nephron development was arrested at the stage of the renal vesicle
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• medulla was not correctly formed in neonates
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• neonates had small metanephroi without nephrons but with normal ureters and normal reproductive tracts
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• neonates had small metanephroi with no nephrons
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• shrunken bladder with no urine
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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