Allele Symbol Allele Name Allele ID |
Lhx1tm2.1Bhr targeted mutation 2.1, Richard R Behringer MGI:2385716 |
||||||||||||||||||||||||
Summary |
5 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• largely absent at E18.5
|
• layer is absent at E18.5
• however, the external granule cell layer appears normal
|
• small at E18.5 compared to controls
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• kidneys are rudimentary in dead neonates
|
• some dead neonates have hydronephrotic kidneys
|
• at E14.5, kidneys are approximately half the size of wild-type kidneys
|
• at 3 weeks, mice displayed renal hypoplasia or renal hypoplasia with unilateral hydronephrosis and megaureter
|
• 2 of 7 neonates necropsied on P1 had duplex kidneys
|
• at E14.5, 20% of mutants have unilateral renal agenesis
|
• the two ureters from the duplex kidneys join before entering bladder
• in some instances, the ureter and bladder do not separate or attach to the bladder
• the ureter is very tortuous
|
• at E11.5, ureteric bud is Y-shaped not T-shaped suggesting branching is impaired
• at E12.4, reduced branching is observed in the ureteric bud
|
• at E11.5, ureteric bud outgrowth is delayed
|
• only rostral-most part of duct forms in mutants
• female sex ducts are rudimentary
|
• at E10.75, extension of the nephric duct to urogenital sinus is impaired
|
• at E14.5, nephric duct is not maintained
|
• male sex ducts are rudimentary
• at E10.75, extension of the nephric duct to urogenital sinus is impaired
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• hypoplastic metanephroi with reduced number of glomeruli
• however, morphologically normal medulla and glomeruli
|
• neonates had small metanephroi that were functional at birth
|
• observed in 40% of mutants
|
• greatly reduced numbers of developing nephrons at birth
|
• the distal ureter was closed in both sexes
|
|
• the distal ureter ended abnormally in the uterus in some females
|
• observed in 40% of mutants
|
• delayed induction of the ureteric bud
|
|
• 57.1% of mutant females had completely or partially absent uteri with residual uterine tissue discontinuously present
• posterior uterus was more frequently absent compared to the anterior region
|
|
• 57.1% of mutant females had completely or partially absent uteri
|
|
• absent epididymis in all mutant males
|
• loss of caudal mesonephric tubules; however, the cranial mesonephros was present
|
• exhibited Mullerian duct aplasia, impaired posterior elongation of the Mullerian duct and Mullerian duct degeneration adjacent to where the Wolffian duct was lost
|
• degeneration of the nephric (Wolffian) duct epithelium that resulted in the absence of most parts of the reproductive tract in all mutant males, except for some residual tissue
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• died within the first day of birth
|
• absent glomeruli and their associated tubules in neonates
|
• nephron development was arrested at the stage of the renal vesicle
|
• medulla was not correctly formed in neonates
|
• neonates had small metanephroi without nephrons but with normal ureters and normal reproductive tracts
|
• neonates had small metanephroi with no nephrons
|
• shrunken bladder with no urine
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/02/2024 MGI 6.24 |
![]() |
|