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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ltb4r1tm1Bodd
targeted mutation 1, Bodduluri Haribabu
MGI:2385781
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ltb4r1tm1Bodd/Ltb4r1tm1Bodd either: (involves: 129S4/SvJaeSor * BALB/c ) or (involves: 129S4/SvJaeSor * C57BL/6) MGI:4822411
hm2
 		Ltb4r1tm1Bodd/Ltb4r1tm1Bodd involves: 129S4/SvJaeSor MGI:3811002
hm3
 		Ltb4r1tm1Bodd/Ltb4r1tm1Bodd involves: 129S4/SvJaeSor * C57BL/6 MGI:3624534


Genotype
MGI:4822411
hm1
Allelic
Composition		 Ltb4r1tm1Bodd/Ltb4r1tm1Bodd
Genetic
Background		 either: (involves: 129S4/SvJaeSor * BALB/c ) or (involves: 129S4/SvJaeSor * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb4r1tm1Bodd mutation (0 available); any Ltb4r1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired neutrophil chemotaxis ( J:163271 )
• in response to Ltb4
decreased susceptibility to induced arthritis ( J:163271 )
• in a K/BxN serum transfer model, mice do not exhibit any inflammation or bone erosion in joints unlike similarly treated wild-type mice

skeleton
decreased susceptibility to induced arthritis ( J:163271 )
• in a K/BxN serum transfer model, mice do not exhibit any inflammation or bone erosion in joints unlike similarly treated wild-type mice

cellular
impaired neutrophil chemotaxis ( J:163271 )
• in response to Ltb4

hematopoietic system
impaired neutrophil chemotaxis ( J:163271 )
• in response to Ltb4




Genotype
MGI:3811002
hm2
Allelic
Composition		 Ltb4r1tm1Bodd/Ltb4r1tm1Bodd
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb4r1tm1Bodd mutation (0 available); any Ltb4r1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to induced arthritis ( J:131779 )
• following treatment with collagen to induce arthritis, mice exhibit no evidence of immune infiltration, pannus formation or fibrillation of the cartilage unlike in similarly treated wild-type mice
• however, mice do produce antibodies against collagen type II

skeleton
decreased susceptibility to induced arthritis ( J:131779 )
• following treatment with collagen to induce arthritis, mice exhibit no evidence of immune infiltration, pannus formation or fibrillation of the cartilage unlike in similarly treated wild-type mice
• however, mice do produce antibodies against collagen type II




Genotype
MGI:3624534
hm3
Allelic
Composition		 Ltb4r1tm1Bodd/Ltb4r1tm1Bodd
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb4r1tm1Bodd mutation (0 available); any Ltb4r1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune disorder ( J:108446 )
• upon adoptive transfer of IRBP1-20-specific T cells from wild-type B6 donors to wild-type and Ltbr4-deficient recipients, wild-type mice develop chronic and severe uveitis, whereas mutant recipients show only mild and transient clinical disease
• adoptive transfer of IRBP1-20-specific Ltbr4-deficient mice to B6 recipients results in moderate uveitis, while transfer to Ltbr4-deficient recipients do not develop disease




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory