Phenotypes associated with this allele

• Allele Symbol: Ren1^tm1Mgfs
• Allele Name: targeted mutation 1, Matthew G F Sharp
• Allele ID: MGI:2385802
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ren1^tm1Mgfs/Ren1^tm1Mgfs	involves: 129P2/OlaHsd	MGI:3699329

Genotype
MGI:3699329

hm1

• Allelic Composition: Ren1^tm1Mgfs/Ren1^tm1Mgfs
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Altered renal morphology in Ren1^tm1Mgfs/Ren1^tm1Mgfs mice

renal/urinary system

abnormal juxtaglomerular cell morphology ( J:41714 )

• complete absence of juxtaglomerular cell granulation

abnormal macula densa morphology ( J:41714 )

• the macula densa of the kidney distal tubule exhibits hypercellularity and an altered epithelial morphology in which the cells show a columnar, instead of a cuboidal, appearance

cardiovascular system

decreased systemic arterial blood pressure ( J:41714 )

• females, but not males, exhibit a decrease in blood pressure of 12.7 mmHg

homeostasis/metabolism

abnormal blood homeostasis ( J:41714 )

• plasma prorenin concentrations are higher in males and females

decreased circulating renin level ( J:41714 )

• plasma renin levels are lower in females but not in males