Phenotypes associated with this allele

• Allele Symbol: Igh-V^tm1Jjk
• Allele Name: targeted mutation 1, James J Kenny
• Allele ID: MGI:2385812
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh-V^tm1Jjk/Igh-V^tm1Jjk	involves: 129S4/SvJae * C57BL/6	MGI:3603543

Genotype
MGI:3603543

hm1

• Allelic Composition: Igh-V^tm1Jjk/Igh-V^tm1Jjk
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal adaptive immunity ( J:62284 )

• Streptococcus pneumoniae R36a fails to elicit an antibody response to cell surface phosphocholine

• T independent responses poor

• although T dependent response was better than the independent response, it was still poor

increased susceptibility to bacterial infection ( J:62284 )

• highly susceptible to infection by encapsulated bacteria