All Phenotypes Spmap2<Tg(PDE5A)1Ynk> MGI Mouse

teratozoospermia ( J:62271 )

• elongated spermatids with either severely abnormal or absent flagella

abnormal sperm axoneme morphology ( J:62271 )

• in elongated spermatids, the microtubules and coarse fibers were abnormally arranged in a whirl, and the cytoplasmic electron density was increased

absent sperm flagellum ( J:62271 )

• sperm flagella may be completely absent

abnormal sperm nucleus morphology ( J:62271 )

• misshapen nuclei in elongated spermatids

abnormal spermatid morphology ( J:62271 )

• intracytoplasmic vacuoles and autophagolysosomes were increased in elongated and some round spermatids

decreased male germ cell number ( J:62271 )

• elongated spermatids were significantly decreased at all stages

• in contrast, normal quantities of spermatogonia and spermatocytes were observed

azoospermia ( J:62271 )

• virtually no spermatozoa in the lumina of seminiferous and epididymal tubules

• however, apoptotic cells were not observed in the lumina of the seminiferous tubules

asthenozoospermia ( J:62271 )

• impaired sperm motility

decreased testis weight ( J:62271 )

• average weight was 60% that of wild-type littermates at 12 weeks of age

male infertility ( J:62271 )