About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcnmb1tm1Rwa
targeted mutation 1, Richard W Aldrich
MGI:2385821
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kcnmb1tm1Rwa/Kcnmb1tm1Rwa involves: 129X1/SvJ * C57BL/6 MGI:3628920
cx2
 		Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Kcnmb4tm1Rwa/Kcnmb4tm1Rwa 		involves: 129X1/SvJ * C57BL/6 MGI:3699110


Genotype
MGI:3628920
hm1
Allelic
Composition		 Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnmb1tm1Rwa mutation (0 available); any Kcnmb1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased heart weight ( J:65415 )
• larger heart-to-body weight ratios
• heart enlargement caused by uncomplicated essential hypertension
increased systemic arterial blood pressure ( J:65415 )
• an increase in mean blood pressure over the pure 129svj mice
abnormal vasoconstriction ( J:65415 )
• cerebral arteries are significantly constricted at a given pressure, indicating an elevation in arterial tone
• the BK channels from mutant arterial smooth muscle are unable to contribute to the regulation of arterial tone

renal/urinary system
abnormal renal glomerular filtration rate ( J:83901 )
• glomerular filtration rate and fractional K+ excretion were significantly impaired in mutant mice in response to acute volume expansion
• no differences in renal function were found under euvolemic conditions
• mutant mice exhibited enhanced Na+ excretion and fractional Na+ excretion in response to acute volume expansion

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:92443 )
N
• mutant mice shows normal hearing function and cochlear structure

muscle
abnormal muscle contractility ( J:106302 )
• urinary bladder smooth muscle strips from mutant mice had elevated phasic contraction amplitude and decreased frequency when compared to control
abnormal vasoconstriction ( J:65415 )
• cerebral arteries are significantly constricted at a given pressure, indicating an elevation in arterial tone
• the BK channels from mutant arterial smooth muscle are unable to contribute to the regulation of arterial tone

growth/size/body
increased heart weight ( J:65415 )
• larger heart-to-body weight ratios
• heart enlargement caused by uncomplicated essential hypertension




Genotype
MGI:3699110
cx2
Allelic
Composition		 Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Kcnmb4tm1Rwa/Kcnmb4tm1Rwa
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnmb1tm1Rwa mutation (0 available); any Kcnmb1 mutation (16 available)
Kcnmb4tm1Rwa mutation (0 available); any Kcnmb4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:117811 )
N
• at 3 weeks, double homozygotes exhibit normal subcellular localization, developmental acquisition, and expression of large conductance voltage- and calcium-activated potassium (BK) channels relative to C57BL/6 wild-type mice
• at 8 weeks, double homozygotes display normal IHC function, as shown by normal ABR thresholds in response to click or pure tone stimuli (4-, 8-, 16-, and 32 kHz) relative to C57BL/6 wild-type mice
• in addition, double homozygotes display normal OHC function, as shown by normal DPOAE magnitudes over a range of frequencies relative to C57BL/6 wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory