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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcnmb1tm1Rwa
targeted mutation 1, Richard W Aldrich
MGI:2385821
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kcnmb1tm1Rwa/Kcnmb1tm1Rwa involves: 129X1/SvJ * C57BL/6 MGI:3628920
cx2
 		Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Kcnmb4tm1Rwa/Kcnmb4tm1Rwa 		involves: 129X1/SvJ * C57BL/6 MGI:3699110


Genotype
MGI:3628920
hm1
Allelic
Composition		 Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnmb1tm1Rwa mutation (0 available); any Kcnmb1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased heart weight ( J:65415 )
• larger heart-to-body weight ratios
• heart enlargement caused by uncomplicated essential hypertension
increased systemic arterial blood pressure ( J:65415 )
• an increase in mean blood pressure over the pure 129svj mice
abnormal vasoconstriction ( J:65415 )
• cerebral arteries are significantly constricted at a given pressure, indicating an elevation in arterial tone
• the BK channels from mutant arterial smooth muscle are unable to contribute to the regulation of arterial tone

renal/urinary system
abnormal renal glomerular filtration rate ( J:83901 )
• glomerular filtration rate and fractional K+ excretion were significantly impaired in mutant mice in response to acute volume expansion
• no differences in renal function were found under euvolemic conditions
• mutant mice exhibited enhanced Na+ excretion and fractional Na+ excretion in response to acute volume expansion

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:92443 )
N
• mutant mice shows normal hearing function and cochlear structure

muscle
abnormal muscle contractility ( J:106302 )
• urinary bladder smooth muscle strips from mutant mice had elevated phasic contraction amplitude and decreased frequency when compared to control
abnormal vasoconstriction ( J:65415 )
• cerebral arteries are significantly constricted at a given pressure, indicating an elevation in arterial tone
• the BK channels from mutant arterial smooth muscle are unable to contribute to the regulation of arterial tone

growth/size/body
increased heart weight ( J:65415 )
• larger heart-to-body weight ratios
• heart enlargement caused by uncomplicated essential hypertension




Genotype
MGI:3699110
cx2
Allelic
Composition		 Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Kcnmb4tm1Rwa/Kcnmb4tm1Rwa
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnmb1tm1Rwa mutation (0 available); any Kcnmb1 mutation (16 available)
Kcnmb4tm1Rwa mutation (0 available); any Kcnmb4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:117811 )
N
• at 3 weeks, double homozygotes exhibit normal subcellular localization, developmental acquisition, and expression of large conductance voltage- and calcium-activated potassium (BK) channels relative to C57BL/6 wild-type mice
• at 8 weeks, double homozygotes display normal IHC function, as shown by normal ABR thresholds in response to click or pure tone stimuli (4-, 8-, 16-, and 32 kHz) relative to C57BL/6 wild-type mice
• in addition, double homozygotes display normal OHC function, as shown by normal DPOAE magnitudes over a range of frequencies relative to C57BL/6 wild-type mice




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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory