Phenotypes associated with this allele

• Allele Symbol: Fosl1^tm1Wag
• Allele Name: targeted mutation 1, Erwin F Wagner
• Allele ID: MGI:2385824
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fosl1^tm1Wag/Fosl1^tm1Wag	either: 129/Sv or (involves: 129/Sv * C57BL/6)	MGI:3655838

Genotype
MGI:3655838

hm1

• Allelic Composition: Fosl1^tm1Wag/Fosl1^tm1Wag
• Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:65292 )

• embryonic lethality around E10

• normal developmental stage at time of death

embryo

abnormal vitelline vasculature morphology ( J:65292 )

• reduced numbers of vitelline blood vessels and small numbers of fetal erythrocytes are present

decreased embryo size ( J:65292 )

• fetuses obviously small in size by E8.5

abnormal parietal yolk sac morphology ( J:65292 )

• parietal yolk sac is made up of Reichert's membrane lined with parietal endodermal cells, but it only has an intermittent layer of trophoblast giant cells rather than the network of channels distributing maternal blood as seen in controls

• considerable separation between visceral and parietal yolk sacs

abnormal placenta morphology ( J:65292 )

abnormal placenta vasculature ( J:65292 )

• although fusion of allantois and chorion is normal, invasion of allantoic blood vessels into the chorionic plate is reduced

abnormal placental labyrinth vasculature morphology ( J:65292 )

• lacks embryonic blood vessels

abnormal chorionic plate morphology ( J:65292 )

• although fusion of allantois and chorion is normal, invasion of allantoic blood vessels into the chorionic plate is reduced

abnormal placenta labyrinth morphology ( J:65292 )

• compact

abnormal visceral yolk sac morphology ( J:65292 )

• considerable separation between visceral and parietal yolk sacs

abnormal visceral yolk sac endoderm morphology ( J:65292 )

• visceral endoderm of yolk sac more compact and unstructured

abnormal visceral endoderm morphology ( J:65292 )

• visceral endoderm of yolk sac is more compact and unstructured

hematopoietic system

abnormal embryonic erythrocyte morphology ( J:65292 )

• some erythrocytes present in vitelline blood vessels are abnormally large

cardiovascular system

abnormal placenta vasculature ( J:65292 )

• although fusion of allantois and chorion is normal, invasion of allantoic blood vessels into the chorionic plate is reduced

abnormal placental labyrinth vasculature morphology ( J:65292 )

• lacks embryonic blood vessels

abnormal vitelline vasculature morphology ( J:65292 )

• reduced numbers of vitelline blood vessels and small numbers of fetal erythrocytes are present

enlarged pericardium ( J:65292 )

• dilated pericardium in some embryos

growth/size/body

decreased embryo size ( J:65292 )

• fetuses obviously small in size by E8.5