Analysis Tools
hematopoietic system
| N |
• mutant mice displayed normal hematocrits and normal total white blood cell counts relative to wild-type mice
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• at 24 hours p.i., the numbers of airway neutrophils were decreased in the bronchoalveolar lavage (but not in the parenchyma) of K. pneumoniae-infected homozygous null mice
• importantly, homozygous null mice showed normal production of other neutrophil chemoattractants, as well as normal neutrophil migration into extrapulmonary tissues relative to wild-type
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immune system
| N |
• resident macrophage, neutrophil, and leukocyte populations in lung tissues were normal
• mutant mice displayed normal leukocyte subpopulations in peripheral blood and bone marrow, with no significant alterations in the absolute or relative numbers of distinct cell types
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• at 24 hours p.i., the numbers of airway neutrophils were decreased in the bronchoalveolar lavage (but not in the parenchyma) of K. pneumoniae-infected homozygous null mice
• importantly, homozygous null mice showed normal production of other neutrophil chemoattractants, as well as normal neutrophil migration into extrapulmonary tissues relative to wild-type
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• both mutant and wild-type mice displayed lethargy and a ruffled coat 48 hours postinoculation (p.i.) with a sublethal dose of Klebsiella pneumoniae; notably, only 56% of mutant mice survived for longer than 10 days relative to an 85% survival rate for wild-type littermates
• at 48 hours p.i., mutants showed a 73-fold increase in lung bacterial burden relative to wild-type
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