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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd27tm1Jbo
targeted mutation 1, Jannie Borst
MGI:2385835
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd27tm1Jbo/Cd27tm1Jbo B6.129P2-Cd27tm1Jbo MGI:3621353
hm2
 		Cd27tm1Jbo/Cd27tm1Jbo either: B6.129P2-CD27tm1Jbo or 129P2/OlaHsd-Tnfrsf7tm1Jbo MGI:3621352
cx3
 		Cd27tm1Jbo/Cd27tm1Jbo
Tg(CD19-Tnfsf7)#Rvl/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3716179


Genotype
MGI:3621353
hm1
Allelic
Composition		 Cd27tm1Jbo/Cd27tm1Jbo
Genetic
Background		 B6.129P2-Cd27tm1Jbo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd27tm1Jbo mutation (1 available); any Cd27 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:198200 )
N
• CD4+ve Foxp3-ve T cell (pre-Treg) numbers in thymus and spleen are comparable to controls; immature thymocyte populations and CD4-ve CD8+ve populations in thymus and spleen are similar to contols
increased T cell apoptosis ( J:198200 )
• cultured Treg cells show significantly higher apoptosis than WT cells but other T cell populations do not
abnormal leukopoiesis ( J:97606 )
• increased capacity to generate myeloid colonies but depressed leukocyte differentiation
decreased regulatory T cell number ( J:198200 )
• frequency and absolute number of CD4+ve Foxp3+ve T (Treg) cells is reduced in adult mice
• frequency and absolute number of CD4+ve Foxp3+ve T cells in thymi of neonates is reduced compared to WT
• treatment with neutralizing antibodies to CD80/CD86 drastically reduces number of Treg cells in the thymus; CD28 signaling blockade reduces number of thymic pre-Treg (CD4+Foxp3-CD25+) cells
increased leukocyte cell number ( J:97606 )
• slightly higher numbers of all white cell lineages in the peripheral blood

hematopoietic system
increased T cell apoptosis ( J:198200 )
• cultured Treg cells show significantly higher apoptosis than WT cells but other T cell populations do not
abnormal leukopoiesis ( J:97606 )
• increased capacity to generate myeloid colonies but depressed leukocyte differentiation
decreased regulatory T cell number ( J:198200 )
• frequency and absolute number of CD4+ve Foxp3+ve T (Treg) cells is reduced in adult mice
• frequency and absolute number of CD4+ve Foxp3+ve T cells in thymi of neonates is reduced compared to WT
• treatment with neutralizing antibodies to CD80/CD86 drastically reduces number of Treg cells in the thymus; CD28 signaling blockade reduces number of thymic pre-Treg (CD4+Foxp3-CD25+) cells
increased leukocyte cell number ( J:97606 )
• slightly higher numbers of all white cell lineages in the peripheral blood

cellular
increased T cell apoptosis ( J:198200 )
• cultured Treg cells show significantly higher apoptosis than WT cells but other T cell populations do not




Genotype
MGI:3621352
hm2
Allelic
Composition		 Cd27tm1Jbo/Cd27tm1Jbo
Genetic
Background		 either: B6.129P2-CD27tm1Jbo or 129P2/OlaHsd-Tnfrsf7tm1Jbo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd27tm1Jbo mutation (1 available); any Cd27 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:65516 )
• thymidine incorporation in T cells exposed to CD3epsilon antibody reduced 1.8x, probably due to reduced survival
• lower response of both CD4+ and CD8+ single positive cells to influenza virus
• reduced memory response
abnormal CD4-positive, alpha-beta T cell physiology ( J:65516 )
• delayed memory response by about 2 days
abnormal cytotoxic T cell physiology ( J:65516 )
• absolute numbers of influenza virus specific CD8+ cells are reduced in the lung
• percentage of influenza virus specific CD8+ cells are reduced in the spleen
• delayed CD8+ memory response

hematopoietic system
abnormal T cell physiology ( J:65516 )
• thymidine incorporation in T cells exposed to CD3epsilon antibody reduced 1.8x, probably due to reduced survival
• lower response of both CD4+ and CD8+ single positive cells to influenza virus
• reduced memory response
abnormal CD4-positive, alpha-beta T cell physiology ( J:65516 )
• delayed memory response by about 2 days
abnormal cytotoxic T cell physiology ( J:65516 )
• absolute numbers of influenza virus specific CD8+ cells are reduced in the lung
• percentage of influenza virus specific CD8+ cells are reduced in the spleen
• delayed CD8+ memory response




Genotype
MGI:3716179
cx3
Allelic
Composition		 Cd27tm1Jbo/Cd27tm1Jbo
Tg(CD19-Tnfsf7)#Rvl/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd27tm1Jbo mutation (1 available); any Cd27 mutation (33 available)
Tg(CD19-Tnfsf7)#Rvl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:88620 )
N
• B cell numbers are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory