All Phenotypes Mpo<tm1Lus> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mpo^tm1Lus/Mpo^tm1Lus	B6.129X1-Mpo^tm1Lus	MGI:3784569
hm2	Mpo^tm1Lus/Mpo^tm1Lus	involves: 129X1/SvJ	MGI:3784544
hm3	Mpo^tm1Lus/Mpo^tm1Lus	involves: 129X1/SvJ * C57BL/6J	MGI:3784539

Allelic Composition	Mpo^tm1Lus/Mpo^tm1Lus
Genetic Background	B6.129X1-Mpo^tm1Lus

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpo^tm1Lus mutation (1 available); any Mpo mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal neutrophil physiology ( J:112488 )

• neutrophils exhibit reduced lysis of muscles cells that are superoxide dismutase treated, mechanically loaded muscle cells whereas lysis by wild-type neutrophils is increased

muscle

abnormal muscle fiber morphology ( J:112488 )

• following an unloading and reloading protocol, muscle fibers exhibit 52% less injury than in wild-type mice and membrane lysis is reduced

homeostasis/metabolism

abnormal response to injury ( J:112488 )

• following an unloading and reloading protocol, muscle fibers exhibit 52% less injury than in wild-type mice and membrane lysis is reduced

hematopoietic system

abnormal neutrophil physiology ( J:112488 )

• neutrophils exhibit reduced lysis of muscles cells that are superoxide dismutase treated, mechanically loaded muscle cells whereas lysis by wild-type neutrophils is increased

Allelic Composition	Mpo^tm1Lus/Mpo^tm1Lus
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpo^tm1Lus mutation (1 available); any Mpo mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:112270 )

• when bone marrow transplanted into irradiated Ldlr^tm1Her homozygotes, mice fed a high fat diet develop 1.9-fold larger atherosclerotic lesions than in Ldlr^tm1Her homozygotes transplanted with wild-type bone marrow

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:67586 , J:126649 )

• following infection with Candida, 40% of mice die by day 20 compared to 100% survival of wild-type mice 65 days after infection (J:67586)

• no mice are alive 5 days after cecal ligation and puncture (CLP) unlike wild-type mice that exhibit 63% survival after 5 days and 38% after 1 week (J:126649)

immune system

increased monocyte cell number ( J:67586 )

• when bone marrow is transplanted into irradiated Ldlr^tm1Her homozygotes, mice fed a high fat, high-cholesterol diet exhibit increased monocyte cells in atherosclerotic lesions compared to Ldlr^tm1Her homozygotes transplanted with wild type bone marrow

abnormal neutrophil physiology ( J:67586 )

• neutrophils fail to produce hypochlorous acid and to chlorinate proteins in vivo

• in culture, neutrophils exhibit reduced killing of Candida and more ingested Candida germinate than when ingested by wild-type neutrophils

increased susceptibility to experimental autoimmune encephalomyelitis ( J:102965 )

• 90% of mice develop hind quarter paralysis following exposure to MOG35-55 peptide in complete Freunds adjuvant (CFA) with pertussis toxin compared to 33% of wild-type mice during 30 days of observation

decreased inflammatory response ( J:102688 )

• asbestos-associated inflammation is delayed compared to in wild-type mice

increased susceptibility to fungal infection ( J:67586 )

• following infection with Candida, 40% of mice die by day 20 compared to 100% survival of wild-type mice 65 days after infection

• unlike wild-type mice, following infection with Candida mice exhibit fungal infiltration of the kidneys

sepsis ( J:126649 )

• no mice are alive 5 days after cecal ligation and puncture (CLP) unlike wild-type mice that exhibit 63% survival after 5 days and 38% after 1 week

• however, cellular response to sepsis is normal

cardiovascular system

atherosclerotic lesions ( J:67586 )

• when bone marrow transplanted into irradiated Ldlr^tm1Her homozygotes, mice fed a high fat, high-cholesterol diet develop 50% larger atherosclerotic lesions than in Ldlr^tm1Her homozygotes transplanted with wild-type bone marrow