All Phenotypes Dmrt1<tm1Zark> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Alpl^tm1(cre)Nagy/Alpl⁺ Dmrt1^tm1Zark/Dmrt1^tm1.1Zark	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3851611
cn2	Dmrt1^tm1Zark/Dmrt1^tm1.1Zark Tg(Dhh-cre)1Mejr/0	involves: 129/Sv * C57BL/6	MGI:3851610

Allelic Composition	Alpl^tm1(cre)Nagy/Alpl⁺ Dmrt1^tm1Zark/Dmrt1^tm1.1Zark
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpl^tm1(cre)Nagy mutation (6 available); any Alpl mutation (352 available)
Dmrt1^tm1.1Zark mutation (0 available); any Dmrt1 mutation (49 available)
Dmrt1^tm1Zark mutation (0 available); any Dmrt1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal spermatogonia morphology ( J:122954 )

• many germ cells fail to migrate to the periphery

decreased male germ cell number ( J:122954 )

• fewer germ cells indicating cells fail to reactivate mitosis

abnormal testis development ( J:122954 )

• many germ cells fail to migrate to the periphery

• however, Sertoli cells are normally polarized

endocrine/exocrine glands

abnormal testis development ( J:122954 )

• many germ cells fail to migrate to the periphery

• however, Sertoli cells are normally polarized

cellular

abnormal spermatogonia morphology ( J:122954 )

• many germ cells fail to migrate to the periphery

decreased male germ cell number ( J:122954 )

• fewer germ cells indicating cells fail to reactivate mitosis

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal testis development ( J:122954 )

• at P9 Sertoli cells are randomly distributed unlike in controls

• at P14 tubules lack luminal space and are instead filled with a poorly organized mix of Sertoli cells and differentiating germ cells

• at P28 tubules contain no apparent germ cells and are filled with randomized, unpolarized Sertoli cells with immature morphology

abnormal Sertoli cell development ( J:122954 )

• Sertoli cells fail to migrate properly and retain an immature morphology at P28

reproductive system

abnormal spermatogonia morphology ( J:122954 )

• by P9 the distribution of germs cells is highly abnormal with more cells in the center and fewer cells at the periphery of the tubules

• meiosis initiates but germ cells are absent by P28

abnormal testis development ( J:122954 )

• at P9 Sertoli cells are randomly distributed unlike in controls

• at P14 tubules lack luminal space and are instead filled with a poorly organized mix of Sertoli cells and differentiating germ cells

• at P28 tubules contain no apparent germ cells and are filled with randomized, unpolarized Sertoli cells with immature morphology

abnormal Sertoli cell development ( J:122954 )

• Sertoli cells fail to migrate properly and retain an immature morphology at P28

cellular

abnormal spermatogonia morphology ( J:122954 )

• by P9 the distribution of germs cells is highly abnormal with more cells in the center and fewer cells at the periphery of the tubules

• meiosis initiates but germ cells are absent by P28

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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