All Phenotypes Rxra<tm1Krc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rxra^tm1Krc/Rxra^tm1Krc Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:4939884
cn2	Myl2^tm1(cre)Krc/Myl2⁺ Rxra^tm1Krc/Rxra^tm1Krc	involves: 129S4/SvJae * Black Swiss	MGI:3620763
cn3	Rxra^tm1Krc/Rxra⁺ Tg(Pbsn-cre)4Prb/0	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:2449982
cn4	Rxra^tm1Krc/Rxra^tm1Krc Tg(Pbsn-cre)4Prb/0	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:2449983

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

increased renal glomerulus apoptosis ( J:168799 )

• increase in the number of apoptotic cells in the glomeruli

increased urine protein level ( J:168799 )

• mutants exhibit excretion of high molecular weight proteins in the urine

albuminuria ( J:168799 )

• mutants exhibit excretion of albumin in the urine

abnormal kidney morphology ( J:168799 )

• females develop severe nephropathy at 4-6 months of age

enlarged kidney ( J:168799 )

• kidney hypertrophy

increased kidney weight ( J:168799 )

• increase in kidney weight due to glomerulomegaly

abnormal nephron morphology ( J:168799 )

• nephrons exhibit coarsening and fusion of podocyte foot processes

abnormal podocyte foot process morphology ( J:168799 )

• cell destruction in the glomeruli is indicated by the accumulation of electrolucent material in podocyte foot processes

fused podocyte foot processes ( J:168799 )

• fusion of podocyte foot processes

increased renal glomerulus basement membrane thickness ( J:168799 )

• glomerular basement membrane thickening

abnormal renal glomerulus morphology ( J:168799 )

• increase in glomerular cell number

increased mesangial cell number ( J:168799 )

• mesangial hypercellularity

glomerulonephritis ( J:168799 )

• severe glomerular inflammation associated with increased renal macrophage infiltration

expanded mesangial matrix ( J:168799 )

• mesangial matrix expansion

renal glomerulus hypertrophy ( J:168799 )

• glomerulomegaly; glomeruli are enlarged in focal regions within the kidneys

homeostasis/metabolism

increased circulating creatine level ( J:168799 )

increased urine protein level ( J:168799 )

• mutants exhibit excretion of high molecular weight proteins in the urine

albuminuria ( J:168799 )

• mutants exhibit excretion of albumin in the urine

immune system

impaired macrophage phagocytosis ( J:168799 )

• peritoneal macrophages exhibit defective phagocytosis resulting in impaired apoptotic cell uptake and an accumulation of apoptotic cells

abnormal peritoneal macrophage morphology ( J:168799 )

• peritoneal macrophages exhibit lower phagosome content and smaller filopodia than control macrophages

increased IgG level ( J:168799 )

• mutants exhibit a marked deposition of IgG in the mesangial matrix

increased IgM level ( J:168799 )

• mutants exhibit a marked deposition of IgM in the mesangial matrix

abnormal macrophage activation involved in immune response ( J:168799 )

• apoptotic cells in mutants cannot reduce proinflammatory response as in controls, indicating enhanced proinflammatory macrophage activation within the kidney glomeruli

increased autoantibody level ( J:168799 )

• mutants develop autoantibodies against nuclear proteins, ssDNA, and dsDNA

increased anti-nuclear antigen antibody level ( J:168799 )

increased anti-double stranded DNA antibody level ( J:168799 )

increased anti-single stranded DNA antibody level ( J:168799 )

glomerulonephritis ( J:168799 )

• severe glomerular inflammation associated with increased renal macrophage infiltration

hematopoietic system

impaired macrophage phagocytosis ( J:168799 )

• peritoneal macrophages exhibit defective phagocytosis resulting in impaired apoptotic cell uptake and an accumulation of apoptotic cells

abnormal peritoneal macrophage morphology ( J:168799 )

• peritoneal macrophages exhibit lower phagosome content and smaller filopodia than control macrophages

increased IgG level ( J:168799 )

• mutants exhibit a marked deposition of IgG in the mesangial matrix

increased IgM level ( J:168799 )

• mutants exhibit a marked deposition of IgM in the mesangial matrix

abnormal macrophage activation involved in immune response ( J:168799 )

• apoptotic cells in mutants cannot reduce proinflammatory response as in controls, indicating enhanced proinflammatory macrophage activation within the kidney glomeruli

cellular

increased mesangial cell number ( J:168799 )

• mesangial hypercellularity

increased renal glomerulus apoptosis ( J:168799 )

• increase in the number of apoptotic cells in the glomeruli

impaired macrophage phagocytosis ( J:168799 )

• peritoneal macrophages exhibit defective phagocytosis resulting in impaired apoptotic cell uptake and an accumulation of apoptotic cells

growth/size/body

enlarged kidney ( J:168799 )

• kidney hypertrophy

increased kidney weight ( J:168799 )

• increase in kidney weight due to glomerulomegaly

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:168799

Allelic Composition	Myl2^tm1(cre)Krc/Myl2⁺ Rxra^tm1Krc/Rxra^tm1Krc
Genetic Background	involves: 129S4/SvJae * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl2^tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)
Rxra^tm1Krc mutation (1 available); any Rxra mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:48085 )

• mutants in which Rxra is specifically deleted in ventricular myocardium are indistinguishable from littermates, grow to adulthood without signs of neonatal dysfunction and hearts do not exhibit any defects, indicating normal fetal ventricular morphogenesis

Allelic Composition	Rxra^tm1Krc/Rxra⁺ Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxra^tm1Krc mutation (1 available); any Rxra mutation (30 available)
Tg(Pbsn-cre)4Prb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal prostate gland branching morphogenesis ( J:78553 )

• branching morphogenesis of the prostate ductal system is increased 54% and 52% in the lateral prostate and anterior prostate, respectively

prostate gland epithelial hyperplasia ( J:78553 )

• prostate hyperplasia after 11 months of age

increased prostate intraepithelial neoplasia incidence ( J:78553 )

• low grade prostatic intraepithelial neoplasia after 14 months of age

• after 18 months of age, some animals progress to high grade prostatic intraepithelial neoplasia

endocrine/exocrine glands

abnormal prostate gland branching morphogenesis ( J:78553 )

• branching morphogenesis of the prostate ductal system is increased 54% and 52% in the lateral prostate and anterior prostate, respectively

prostate gland epithelial hyperplasia ( J:78553 )

• prostate hyperplasia after 11 months of age

increased prostate intraepithelial neoplasia incidence ( J:78553 )

• low grade prostatic intraepithelial neoplasia after 14 months of age

• after 18 months of age, some animals progress to high grade prostatic intraepithelial neoplasia

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:78553 )

• low grade prostatic intraepithelial neoplasia after 14 months of age

• after 18 months of age, some animals progress to high grade prostatic intraepithelial neoplasia

Allelic Composition	Rxra^tm1Krc/Rxra^tm1Krc Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxra^tm1Krc mutation (1 available); any Rxra mutation (30 available)
Tg(Pbsn-cre)4Prb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal prostate gland branching morphogenesis ( J:78553 )

• branching morphogenesis of the prostate ductal system is increased 54% and 52% in the lateral prostate and anterior prostate, respectively

increased prostate intraepithelial neoplasia incidence ( J:78553 )

• 71% incidence of prostatic intraepithelial neoplasia after 4 months of age

• lesions progress to low grade prostatic intraepithelial neoplasia after 5 months of age

• after 10 months of age, some animals progress to high grade prostatic intraepithelial neoplasia

abnormal prostate gland physiology ( J:78553 )

• change in protein profile of secretory proteins

• increase in prostatic cell proliferation rate

endocrine/exocrine glands

abnormal prostate gland branching morphogenesis ( J:78553 )

• branching morphogenesis of the prostate ductal system is increased 54% and 52% in the lateral prostate and anterior prostate, respectively

increased prostate intraepithelial neoplasia incidence ( J:78553 )

• 71% incidence of prostatic intraepithelial neoplasia after 4 months of age

• lesions progress to low grade prostatic intraepithelial neoplasia after 5 months of age

• after 10 months of age, some animals progress to high grade prostatic intraepithelial neoplasia

abnormal prostate gland physiology ( J:78553 )

• change in protein profile of secretory proteins

• increase in prostatic cell proliferation rate

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:78553 )

• 71% incidence of prostatic intraepithelial neoplasia after 4 months of age

• lesions progress to low grade prostatic intraepithelial neoplasia after 5 months of age

• after 10 months of age, some animals progress to high grade prostatic intraepithelial neoplasia

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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