Phenotypes associated with this allele

• Allele Symbol: Nfe2l1^tm1Tow
• Allele Name: targeted mutation 1, Timothy Townes
• Allele ID: MGI:2385936
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfe2l1^tm1Tow/Nfe2l1^tm1Tow	involves: 129S1/Sv * 129X1/SvJ	MGI:2672109

Genotype
MGI:2672109

hm1

• Allelic Composition: Nfe2l1^tm1Tow/Nfe2l1^tm1Tow
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:39447 )

• majority of embryos die between E6.5 and E7.5

embryo

absent mesoderm ( J:39447 )

• neither embryonic or extra-embryonic mesoderm is present in E6.5 embryos

failure of primitive streak formation ( J:39447 )

• primitive streak formation is absent in E6.5 embryos

hematopoietic system

abnormal hematopoietic system morphology/development ( J:39447 )

• ES cells differentiated in vitro produce much less red blood cells than controls