Phenotypes associated with this allele

• Allele Symbol: Nrf1^tm1Rcs
• Allele Name: targeted mutation 1, Richard C Scarpulla
• Allele ID: MGI:2385947
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nrf1^tm1Rcs/Nrf1^tm1Rcs	involves: 129X1/SvJ	MGI:3828261

Genotype
MGI:3828261

hm1

• Allelic Composition: Nrf1^tm1Rcs/Nrf1^tm1Rcs
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:67376 )

• mice die between E3.5 and E6.5

cellular

abnormal mitochondrial morphology ( J:67376 )

• E3.5 embryos exhibit decreased mitochondrial staining and contain 30% to less than 5% mitochondrial DNA compared to wild-type embryos

decreased cell proliferation ( J:67376 )

• in culture, blastocysts fail to attach and show no signs of proliferation unlike wild-type blastocysts