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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Serpinh1tm1Kzn
targeted mutation 1, Kazuhiro Nagata
MGI:2385994
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Serpinh1tm1Kzn/Serpinh1tm1Kzn either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR) MGI:3037426


Genotype
MGI:3037426
hm1
Allelic
Composition		 Serpinh1tm1Kzn/Serpinh1tm1Kzn
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpinh1tm1Kzn mutation (1 available); any Serpinh1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:64899 )
• death occurs between E10.5 and E11.5

embryo
abnormal embryonic tissue morphology ( J:64899 )
• E10.5 embryos with a low cell density
• translucent and very fragile
abnormal embryonic neuroepithelium morphology ( J:64899 )
• neuroepithelial cell distribution disordered
abnormal somite development ( J:64899 )
• reduced numbers of somites are formed

nervous system
abnormal embryonic neuroepithelium morphology ( J:64899 )
• neuroepithelial cell distribution disordered




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory