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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nr1i2tm1Rev
targeted mutation 1, Ronald M Evans
MGI:2386087
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nr1i2tm1Rev/Nr1i2tm1Rev involves: 129S4/SvJae * C57BL/6J MGI:3041680


Genotype
MGI:3041680
hm1
Allelic
Composition		 Nr1i2tm1Rev/Nr1i2tm1Rev
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1i2tm1Rev mutation (0 available); any Nr1i2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:63639 )
• exhibit a specific loss of xenoregulation of CYP3A11
• Cyp3a11 is no longer induced in response to the prototypic rodent-specific CYP3A11 inducers, pregnenolone-16alpha-carbonitrile and dexamethasone
• loss of inducibility is restricted to target genes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory