All Phenotypes Rara<tm3.1Ipc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rara^tm3.1Ipc
targeted mutation 3.1, Pierre Chambon
MGI:2386107

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rara^tm3.1Ipc/Rara^tm3.1Ipc	involves: 129/Sv * C57BL/6 * SJL	MGI:3622910
cx2	Rara^tm3.1Ipc/Rara⁺ Trim24^tm1.1Los/Trim24^tm1.1Los	involves: 129/Sv * C57BL/6 * SJL	MGI:3772095

Allelic Composition	Rara^tm3.1Ipc/Rara^tm3.1Ipc
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rara^tm3.1Ipc mutation (0 available); any Rara mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal testis morphology ( J:75135 )

• testicular degeneration manifested by the sloughing of immature germ cells in the lumen of seminiferous tubules

male infertility ( J:75135 )

endocrine/exocrine glands

abnormal testis morphology ( J:75135 )

• testicular degeneration manifested by the sloughing of immature germ cells in the lumen of seminiferous tubules

Allelic Composition	Rara^tm3.1Ipc/Rara⁺ Trim24^tm1.1Los/Trim24^tm1.1Los
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rara^tm3.1Ipc mutation (0 available); any Rara mutation (79 available)
Trim24^tm1.1Los mutation (0 available); any Trim24 mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

increased hepatocyte proliferation ( J:130210 )

• there is about a 3-fold increase in the number of Ki67-positive hepatocytes in 14 week old mice

• this number of Ki67-positive hepatocytes 40% less than the number found in age-matched mice that are homozygous null for Trim24 but homozygous wild-type for Rara

neoplasm

neoplasm ( J:130210 )

N	• no liver tumors are found in mice between 12 and 15 months of age compared to 70% liver tumor incidence in age-matched mice that are homozygous null for Trim24 but homozygous wild-type for Rara

cellular

increased hepatocyte proliferation ( J:130210 )

• there is about a 3-fold increase in the number of Ki67-positive hepatocytes in 14 week old mice

• this number of Ki67-positive hepatocytes 40% less than the number found in age-matched mice that are homozygous null for Trim24 but homozygous wild-type for Rara

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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