All Phenotypes Rarg<tm3Ipc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rarg^tm3Ipc
targeted mutation 3, Pierre Chambon
MGI:2386111

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rarb^tm2Ipc/Rarb^tm2Ipc Rarg^tm3Ipc/Rarg^tm3Ipc H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129/Sv * C57BL/6 * SJL	MGI:3620540
cn2	Rarg^tm3Ipc/Rarg^tm3Ipc Tg(CMV-cre/ERT)1Ipc/0	involves: C57BL/6 * SJL	MGI:3629391
cn3	Rarg^tm3Ipc/Rarg^tm3Ipc Tg(KRT14-cre)1Ipc/0	involves: C57BL/6 * SJL	MGI:3629393
cn4	Rarg^tm3Ipc/Rarg^tm3Ipc Tg(KRT14-cre/ERT2)1Ipc/0	Not Specified	MGI:3629392

Allelic Composition	Rarb^tm2Ipc/Rarb^tm2Ipc Rarg^tm3Ipc/Rarg^tm3Ipc H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Rarb^tm2Ipc mutation (0 available); any Rarb mutation (40 available)
Rarg^tm3Ipc mutation (1 available); any Rarg mutation (151 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased periocular mesenchyme apoptosis ( J:102847 )

• at E10.5 and E11.5 no apoptosis is seen in dorsal and ventral cluster of cells in the periocular mesenchyme where apoptosis is seen in wild-type mice

vision/eye

abnormal conjunctival sac morphology ( J:102847 )

• a small, abnormal conjuctival sac is present at E14.5

ventral rotation of lens ( J:102847 )

• severe ventral rotation of the lens

abnormal eye development ( J:102847 )

• at E14.5, a thick layer of mesenchyme replaces the eyelids and cornea and a small, abnormal conjuctival sac is present

decreased periocular mesenchyme apoptosis ( J:102847 )

• at E10.5 and E11.5 no apoptosis is seen in dorsal and ventral cluster of cells in the periocular mesenchyme where apoptosis is seen in wild-type mice

persistent hyperplastic primary vitreous ( J:102847 )

• retrolenticular membrane resulting from the persistence and hyperplasia of the primary vitreous body

decreased ventral retina size ( J:102847 )

• severe shortening of the ventral retina

embryo

decreased periocular mesenchyme apoptosis ( J:102847 )

• at E10.5 and E11.5 no apoptosis is seen in dorsal and ventral cluster of cells in the periocular mesenchyme where apoptosis is seen in wild-type mice

growth/size/body

decreased periocular mesenchyme apoptosis ( J:102847 )

• at E10.5 and E11.5 no apoptosis is seen in dorsal and ventral cluster of cells in the periocular mesenchyme where apoptosis is seen in wild-type mice

Allelic Composition	Rarg^tm3Ipc/Rarg^tm3Ipc Tg(CMV-cre/ERT)1Ipc/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rarg^tm3Ipc mutation (1 available); any Rarg mutation (151 available)
Tg(CMV-cre/ERT)1Ipc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin morphology ( J:109090 )

• phenotype of adult mutant epidermis is identical to that observed in Rarg^tm1Ipc newborns

• skin from adult mice with selective Rarg ablation in the suprabasal layer upon tamoxifen treatment displays a smooth surface with small or lacking corneodesmosomes (CDs), compared to wild-type which have numerous regularly spaced plaques corresponding to CDs

abnormal epidermis stratum corneum morphology ( J:109090 )

• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis

abnormal keratinocyte morphology ( J:109090 )

• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae

• disorganized lamellae form aggregates at the apical pole of granular keratinocytes

Allelic Composition	Rarg^tm3Ipc/Rarg^tm3Ipc Tg(KRT14-cre)1Ipc/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rarg^tm3Ipc mutation (1 available); any Rarg mutation (151 available)
Tg(KRT14-cre)1Ipc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired skin barrier function ( J:109090 )

• at birth, no apparent defect is observed but in adult homozygotes, transepidermal water loss is increased (7.51 g/hr vs 6.48 g/hr in controls

integument

impaired skin barrier function ( J:109090 )

• at birth, no apparent defect is observed but in adult homozygotes, transepidermal water loss is increased (7.51 g/hr vs 6.48 g/hr in controls

abnormal epidermal layer morphology ( J:109090 )

abnormal epidermis stratum corneum morphology ( J:109090 )

abnormal keratinocyte morphology ( J:109090 )

shiny skin ( J:109090 )

• newborns have skin with glossy appearance

Allelic Composition	Rarg^tm3Ipc/Rarg^tm3Ipc Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rarg^tm3Ipc mutation (1 available); any Rarg mutation (151 available)
Tg(KRT14-cre/ERT2)1Ipc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin morphology ( J:109090 )

• phenotype of adult mutant epidermis is identical to that observed in Rarg^tm1Ipc newborns

• sqaumes from adult mice with Rarg ablation in all epidermal layers display a smooth surface with small or lacking corneodesmosomes (CDs), compared to wild-type which have numerous regularly spaced plaques corresponding to CDs

abnormal epidermis stratum corneum morphology ( J:109090 )

• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis

abnormal keratinocyte morphology ( J:109090 )

• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae

• disorganized lamellae form aggregates at the apical pole of granular keratinocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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