Phenotypes associated with this allele

• Allele Symbol: Tapbp^tm1Gjh
• Allele Name: targeted mutation 1, Gunter J Hammerling
• Allele ID: MGI:2386113
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tapbp^tm1Gjh/Tapbp^tm1Gjh	involves: 129S2/SvPas	MGI:3694696

Genotype
MGI:3694696

hm1

• Allelic Composition: Tapbp^tm1Gjh/Tapbp^tm1Gjh
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell number ( J:64349 )

• CD8+ T cell number in periphery, and in thymus, is reduced

abnormal NK cell physiology ( J:64349 )

• NK cells from mutants have altered specificity and are self-tolerant

decreased cytotoxic T cell cytolysis ( J:64349 )

• influenza virus-specific cytotoxic T lymphocyte (CTL) activity is reduced in mutants

• mutants do not generate a CTL response to syngeneic antigens, indicating tolerance due to overlap of peptide repertoires; a reduced response against alloantigens is observed, but after in vivo priming is similar to wild-type

abnormal dendritic cell antigen presentation ( J:64349 )

• CD8+ T cell responses to virus and protein antigen are reduced due to inability of dendritic cells to efficiently present antigen

• dendritic cells are unable to present ovalbumin via MHC class I molecules to an OVA-specific hybridoma

abnormal antigen presentation via MHC class I ( J:64349 )

• dendritic cells are unable to present ovalbumin via MHC class I molecules to an OVA-specific hybridoma

• peptides exhibit less stable binding to MHC class I molecules, resulting in less stable class I molecules

decreased level of surface class I molecules ( J:64349 )

• splenocytes exhibit ~90% reduction of MHC class I H-2K^b and H-2D^b expression; similar results are found for lymph node cells and peripheral blood lymphocytes

hematopoietic system

decreased T cell number ( J:64349 )

• CD8+ T cell number in periphery, and in thymus, is reduced

abnormal NK cell physiology ( J:64349 )

• NK cells from mutants have altered specificity and are self-tolerant

decreased cytotoxic T cell cytolysis ( J:64349 )

• influenza virus-specific cytotoxic T lymphocyte (CTL) activity is reduced in mutants

• mutants do not generate a CTL response to syngeneic antigens, indicating tolerance due to overlap of peptide repertoires; a reduced response against alloantigens is observed, but after in vivo priming is similar to wild-type