Phenotypes associated with this allele

• Allele Symbol: Rorc^tm1Amj
• Allele Name: targeted mutation 1, Anton M Jetten
• Allele ID: MGI:2386114
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rorc^tm1Amj/Rorc^tm1Amj	either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)	MGI:3796174

Genotype
MGI:3796174

hm1

• Allelic Composition: Rorc^tm1Amj/Rorc^tm1Amj
• Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * DBA/2)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymus weight ( J:64381 )

• thymus exhibits 15-20% reduction in weight compared to wild-type

thymus hypoplasia ( J:64381 )

• total number of thymocytes retrieved from thymus is 74% lower than wild-type

enlarged spleen ( J:64381 )

• spleen is 2-fold larger than wild-type, but follicular dendritic cell network and germinal centers are intact

increased double-negative T cell number ( J:64381 )

• percentage of double negative (DN) cells is significantly enhanced compared to wild-type

decreased T cell number ( J:64381 )

decreased double-positive T cell number ( J:64381 )

• percentage of double-positive (DP) thymocytes is reduced by 75%

decreased CD4-positive, alpha-beta T cell number ( J:64381 )

• T lymphopenia is exhibited with 10-fold reduction in circulating CD4+ T cells

• percentage of CD4+ thymocytes is reduced; number of SP cells in thymus is reduced by 87%

decreased CD8-positive, alpha-beta T cell number ( J:64381 )

• T lymphopenia is exhibited with 3-fold reduction in circulating CD8+ T cells

• number of SP cells in thymus is reduced by 55%

abnormal splenic cell ratio ( J:64381 )

• spleen contains 3-fold more lymphocytes than wild-type

• number of B lymphocytes (B220+) is increased relative to T lymphocytes (CD3+)

• percentage of CD4+ cells in spleen is slightly reduced

abnormal T cell physiology ( J:64381 )

• percentage of thymocytes in S phase of cell cycle is dramatically increased compared to wild-type

increased T cell apoptosis ( J:64381 )

• thymus exhibits 4-fold higher TUNEL-positive cells than wild-type; apoptotic cells are found in cortex region, not in medulla; enhanced apoptosis is associated with DP thymocytes

abnormal interleukin level ( J:123351 )

• activated T_H cells from mutants produce no Il-17, Il-17F or Il-22

abnormal lymph organ development ( J:64381 )

• development is completely arrested resulting in absence of lymph nodes and Peyer's patches

absent Peyer's patches ( J:64381 )

• absence observed at necropsy

absent lymph nodes ( J:64381 )

• observed at necropsy; peripheral, para-aortic, and mesenteric lymph nodes are not found

hematopoietic system

decreased thymus weight ( J:64381 )

• thymus exhibits 15-20% reduction in weight compared to wild-type

thymus hypoplasia ( J:64381 )

• total number of thymocytes retrieved from thymus is 74% lower than wild-type

enlarged spleen ( J:64381 )

• spleen is 2-fold larger than wild-type, but follicular dendritic cell network and germinal centers are intact

increased double-negative T cell number ( J:64381 )

• percentage of double negative (DN) cells is significantly enhanced compared to wild-type

decreased T cell number ( J:64381 )

decreased double-positive T cell number ( J:64381 )

• percentage of double-positive (DP) thymocytes is reduced by 75%

decreased CD4-positive, alpha-beta T cell number ( J:64381 )

• T lymphopenia is exhibited with 10-fold reduction in circulating CD4+ T cells

• percentage of CD4+ thymocytes is reduced; number of SP cells in thymus is reduced by 87%

decreased CD8-positive, alpha-beta T cell number ( J:64381 )

• T lymphopenia is exhibited with 3-fold reduction in circulating CD8+ T cells

• number of SP cells in thymus is reduced by 55%

abnormal splenic cell ratio ( J:64381 )

• spleen contains 3-fold more lymphocytes than wild-type

• number of B lymphocytes (B220+) is increased relative to T lymphocytes (CD3+)

• percentage of CD4+ cells in spleen is slightly reduced

abnormal T cell physiology ( J:64381 )

• percentage of thymocytes in S phase of cell cycle is dramatically increased compared to wild-type

increased T cell apoptosis ( J:64381 )

• thymus exhibits 4-fold higher TUNEL-positive cells than wild-type; apoptotic cells are found in cortex region, not in medulla; enhanced apoptosis is associated with DP thymocytes

homeostasis/metabolism

abnormal interleukin level ( J:123351 )

• activated T_H cells from mutants produce no Il-17, Il-17F or Il-22

cellular

increased T cell apoptosis ( J:64381 )

• thymus exhibits 4-fold higher TUNEL-positive cells than wild-type; apoptotic cells are found in cortex region, not in medulla; enhanced apoptosis is associated with DP thymocytes

endocrine/exocrine glands

decreased thymus weight ( J:64381 )

• thymus exhibits 15-20% reduction in weight compared to wild-type

thymus hypoplasia ( J:64381 )

• total number of thymocytes retrieved from thymus is 74% lower than wild-type

growth/size/body

enlarged spleen ( J:64381 )

• spleen is 2-fold larger than wild-type, but follicular dendritic cell network and germinal centers are intact