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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pigatm1Bsl
targeted mutation 1, Monica Bessler
MGI:2386121
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pigatm1Bsl/Piga+
Tg(FES-cre)31Bsl/0 		involves: 129S1/Sv * C57BL/6 * CBA/Ca MGI:3814205
cn2
 		Pigatm1Bsl/Y
Tg(FES-cre)31Bsl/0 		involves: 129S1/Sv * C57BL/6 * CBA/Ca MGI:3814206
cn3
 		Pigatm1Bsl/Piga+
Tg(EIIa-cre)C5379Lmgd/0 		involves: 129S1/Sv * FVB/NJ MGI:3814198


Genotype
MGI:3814205
cn1
Allelic
Composition		 Pigatm1Bsl/Piga+
Tg(FES-cre)31Bsl/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pigatm1Bsl mutation (0 available); any Piga mutation (3 available)
Tg(FES-cre)31Bsl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
weight loss ( J:71354 )
• developing around 12 months of age

behavior/neurological
weakness ( J:71354 )
• general muscular weakness after 12 months of age
decreased locomotor activity ( J:71354 )
• decreased overall activity after 12 months of age

neoplasm
increased hemangioma incidence ( J:71354 )
• sometimes seen in spleen and lymph nodes at 12 months of age
increased B cell derived lymphoma incidence ( J:71354 )
• sometimes seen in spleen and lymph nodes at 12 months of age




Genotype
MGI:3814206
cn2
Allelic
Composition		 Pigatm1Bsl/Y
Tg(FES-cre)31Bsl/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pigatm1Bsl mutation (0 available); any Piga mutation (3 available)
Tg(FES-cre)31Bsl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
weight loss ( J:71354 )
• developing around 12 months of age

behavior/neurological
weakness ( J:71354 )
• general muscular weakness after 12 months of age
abnormal gait ( J:71354 )
• wide gait in males only, after 12 months of age
decreased locomotor activity ( J:71354 )
• decreased overall activity after 12 months of age

neoplasm
increased hemangioma incidence ( J:71354 )
• sometimes seen in spleen and lymph nodes at 12 months of age
increased B cell derived lymphoma incidence ( J:71354 )
• sometimes seen in spleen and lymph nodes at 12 months of age




Genotype
MGI:3814198
cn3
Allelic
Composition		 Pigatm1Bsl/Piga+
Tg(EIIa-cre)C5379Lmgd/0
Genetic
Background		 involves: 129S1/Sv * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pigatm1Bsl mutation (0 available); any Piga mutation (3 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:75506 )
• increased perinatal lethality

hematopoietic system
abnormal definitive hematopoiesis ( J:75506 )
• high level of blood cells lacking glycosylphosphatidylinositol anchors
abnormal erythrocyte morphology ( J:75506 )
• level of RBC lacking glycosylphosphatidylinositol anchors highest at birth (up to 53%) and declining over 4 weeks to around 4%
reticulocytosis ( J:75506 )
• elevated numbers of reticulocytes
abnormal erythrocyte physiology ( J:75506 )
• RBC half life only 50% of normal
increased erythrocyte osmotic fragility ( J:75506 )
• increased susceptibility to lytic activity of activated complement

craniofacial
abnormal facial morphology ( J:56055 )
• orofacial abnormalities when cre recombination levels are highest
cleft palate ( J:56055 )
• when cre recombination levels are highest

behavior/neurological
abnormal suckling behavior ( J:56055 )
• unable to suckle when cre recombination levels are highest

digestive/alimentary system
cleft palate ( J:56055 )
• when cre recombination levels are highest

growth/size/body
abnormal facial morphology ( J:56055 )
• orofacial abnormalities when cre recombination levels are highest
cleft palate ( J:56055 )
• when cre recombination levels are highest




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory