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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lilrb4atm1Eol
targeted mutation 1, Eric O Long
MGI:2386122
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lilrb4atm1Eol/Lilrb4atm1Eol B6.129P2-Lilrb4atm1Eol MGI:3842769
hm2
Lilrb4atm1Eol/Lilrb4atm1Eol involves: 129P2/OlaHsd * C57BL/6 MGI:3842767


Genotype
MGI:3842769
hm1
Allelic
Composition
Lilrb4atm1Eol/Lilrb4atm1Eol
Genetic
Background
B6.129P2-Lilrb4atm1Eol
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lilrb4atm1Eol mutation (0 available); any Lilrb4a mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in ragweed sensitized mice also infected with Ascaris suum
• in ragweed sensitized mice also infected with Ascaris suum
• increased neutrophiles in the conjunctiva 72 hours after ocular challenge
• increase in eosinophile infiltration of conjunctiva 72 hours after ragweed challenge is greater than for control mice
• lung infiltration is increased relative to controls but not to a statistically significant extent after ragweed challenge
• cell infiltrates are further elevated in ragweed sensitized mice also infected with Ascaris suum
• after ocular challenge of ragweed sensitized mice
• IgE serum response to ragweed challenge in sensitized mice is lower than for controls
• interferon gamma levels recovered by lung lavage in ragweed sensitized, then challenged mice are very low
• significantly elevated levels of Il4 and Il13 are recovered by lavage from lungs than recovered from controls, after ragweed challenge
• increased interstitial inflammation in ragweed sensitized mice also infected with Ascaris suum

respiratory system
• increased mucus production in ragweed sensitized mice also infected with Ascaris suum

hematopoietic system
• in ragweed sensitized mice also infected with Ascaris suum
• in ragweed sensitized mice also infected with Ascaris suum
• increased neutrophiles in the conjunctiva 72 hours after ocular challenge
• increase in eosinophile infiltration of conjunctiva 72 hours after ragweed challenge is greater than for control mice
• lung infiltration is increased relative to controls but not to a statistically significant extent after ragweed challenge
• cell infiltrates are further elevated in ragweed sensitized mice also infected with Ascaris suum
• after ocular challenge of ragweed sensitized mice
• IgE serum response to ragweed challenge in sensitized mice is lower than for controls

homeostasis/metabolism
• interferon gamma levels recovered by lung lavage in ragweed sensitized, then challenged mice are very low
• significantly elevated levels of Il4 and Il13 are recovered by lavage from lungs than recovered from controls, after ragweed challenge

cellular
• increased neutrophiles in the conjunctiva 72 hours after ocular challenge
• increase in eosinophile infiltration of conjunctiva 72 hours after ragweed challenge is greater than for control mice
• lung infiltration is increased relative to controls but not to a statistically significant extent after ragweed challenge
• cell infiltrates are further elevated in ragweed sensitized mice also infected with Ascaris suum
• after ocular challenge of ragweed sensitized mice




Genotype
MGI:3842767
hm2
Allelic
Composition
Lilrb4atm1Eol/Lilrb4atm1Eol
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lilrb4atm1Eol mutation (0 available); any Lilrb4a mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory