All Phenotypes Gjc1<tm1Kwi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gjc1^tm1Kwi
targeted mutation 1, Klaus Willecke
MGI:2386124

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gjc1^tm1Kwi/Gjc1^tm1Weil Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3582061
cn2	Gjc1^tm1Kwi/Gjc1^tm1Kwi Tg(Myh6-icre/ERT2)#Wet/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5544304
cn3	Gjc1^tm1Kwi/Gjc1^tm1Kwi Gjd3^tm2.1Kwi/Gjd3^tm2.1Kwi Tg(Myh6-icre/ERT2)#Wet/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5544303

Allelic Composition	Gjc1^tm1Kwi/Gjc1^tm1Weil Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc1^tm1Kwi mutation (1 available); any Gjc1 mutation (33 available)
Gjc1^tm1Weil mutation (1 available); any Gjc1 mutation (33 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye electrophysiology ( J:95984 )

• scotopic electroretinogram recordings in response to 20 msec white light flashes in dark-adapted mutants showed that b-wave amplitudes were 40% smaller than in wild-type controls but a-waves did not differ, indicating a defect in the rod driven circuitry

Allelic Composition	Gjc1^tm1Kwi/Gjc1^tm1Kwi Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc1^tm1Kwi mutation (1 available); any Gjc1 mutation (33 available)
Tg(Myh6-icre/ERT2)#Wet mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:205110 )

• embryos treated with tamoxifen at E8.5 and E9.5 die beyond E10.5

• however, mice not treated with tamoxifen develop normally

cardiovascular system

cardiovascular system phenotype ( J:205110 )

N	• tamoxifen-treated mice do not exhibit spontaneous AV block, supraventricular or ventricular ectopic beats or arrhythmia

abnormal heart electrocardiography waveform feature ( J:205110 )

• tamoxifen-treated mice exhibit prolonged atria-His (AH) interval compared with control mice

prolonged PQ interval ( J:205110 )

• in tamoxifen-treated mice

abnormal sinoatrial node conduction ( J:205110 )

• tamoxifen-treated mice exhibit shorter sinus node recovery rate compared with control mice

Allelic Composition	Gjc1^tm1Kwi/Gjc1^tm1Kwi Gjd3^tm2.1Kwi/Gjd3^tm2.1Kwi Tg(Myh6-icre/ERT2)#Wet/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc1^tm1Kwi mutation (1 available); any Gjc1 mutation (33 available)
Gjd3^tm2.1Kwi mutation (1 available); any Gjd3 mutation (13 available)
Tg(Myh6-icre/ERT2)#Wet mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:205110 )

N	• tamoxifen-treated mice are viable

cardiovascular system

cardiovascular system phenotype ( J:205110 )

N	• tamoxifen-treated mice exhibit normal heart morphology, equal heart rates, P-wave duration, QRS intervals and QTc intervals without spontaneous AV block, supraventricular or ventricular ectopic beats or arrhythmia

abnormal heart electrocardiography waveform feature ( J:205110 )

• tamoxifen-treated mice exhibit prolonged atria-His (AH) interval and Wenckebach periodicity compared with control mice

prolonged PQ interval ( J:205110 )

• in tamoxifen-treated mice

abnormal sinoatrial node conduction ( J:205110 )

• tamoxifen-treated mice exhibit shorter sinus node recovery rate compared with control mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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