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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(FES-cre)31Bsl
transgene insertion 31, Monica Bessler
MGI:2386125
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pigatm1Tak/Pigatm1Tak
Tg(FES-cre)31Bsl/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/Ca MGI:6304006
cn2
 		Pigatm1Bsl/Piga+
Tg(FES-cre)31Bsl/0 		involves: 129S1/Sv * C57BL/6 * CBA/Ca MGI:3814205
cn3
 		Pigatm1Bsl/Y
Tg(FES-cre)31Bsl/0 		involves: 129S1/Sv * C57BL/6 * CBA/Ca MGI:3814206


Genotype
MGI:6304006
cn1
Allelic
Composition		 Pigatm1Tak/Pigatm1Tak
Tg(FES-cre)31Bsl/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pigatm1Tak mutation (1 available); any Piga mutation (3 available)
Tg(FES-cre)31Bsl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell morphology ( J:162065 )
• mice show the appearance of clonally-restricted, inactive yet functionally competent CD8 T cells, with an enrichment of CD8 T cells that lack glycosyl phosphatidylinositol (GPI) and GPI-anchored proteins in the blood, marrow, and spleen and enrichment of GPI- CD4 T cells in the spleen, and with pronounced Vbeta5.1/5.2 skewing of GPI- T cells
• however, mice do not show bone marrow failure, autoimmunity, or hemoglobinuria despite reduced immunosuppressive Treg cells
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:162065 )
• the proportion of CD4+CD25+FoxP3+ regulatory T cells is lower in peripheral blood
• however, there are no differences in the proportion of natural killer T cells in peripheral blood
abnormal T cell physiology ( J:162065 )
• mice exhibit fewer GPI- gamma-interferon producing CD8 T and CD4 T cells after lectin stimulation with myristate acetate and ionomycin
abnormal T cell activation ( J:162065 )
• marker analysis indicates that the enlarged pool of GPI- CD8 T cells is less activated than normal T cells

immune system
abnormal T cell morphology ( J:162065 )
• mice show the appearance of clonally-restricted, inactive yet functionally competent CD8 T cells, with an enrichment of CD8 T cells that lack glycosyl phosphatidylinositol (GPI) and GPI-anchored proteins in the blood, marrow, and spleen and enrichment of GPI- CD4 T cells in the spleen, and with pronounced Vbeta5.1/5.2 skewing of GPI- T cells
• however, mice do not show bone marrow failure, autoimmunity, or hemoglobinuria despite reduced immunosuppressive Treg cells
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:162065 )
• the proportion of CD4+CD25+FoxP3+ regulatory T cells is lower in peripheral blood
• however, there are no differences in the proportion of natural killer T cells in peripheral blood
abnormal T cell physiology ( J:162065 )
• mice exhibit fewer GPI- gamma-interferon producing CD8 T and CD4 T cells after lectin stimulation with myristate acetate and ionomycin
abnormal T cell activation ( J:162065 )
• marker analysis indicates that the enlarged pool of GPI- CD8 T cells is less activated than normal T cells




Genotype
MGI:3814205
cn2
Allelic
Composition		 Pigatm1Bsl/Piga+
Tg(FES-cre)31Bsl/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pigatm1Bsl mutation (0 available); any Piga mutation (3 available)
Tg(FES-cre)31Bsl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
weight loss ( J:71354 )
• developing around 12 months of age

behavior/neurological
weakness ( J:71354 )
• general muscular weakness after 12 months of age
decreased locomotor activity ( J:71354 )
• decreased overall activity after 12 months of age

neoplasm
increased hemangioma incidence ( J:71354 )
• sometimes seen in spleen and lymph nodes at 12 months of age
increased B cell derived lymphoma incidence ( J:71354 )
• sometimes seen in spleen and lymph nodes at 12 months of age




Genotype
MGI:3814206
cn3
Allelic
Composition		 Pigatm1Bsl/Y
Tg(FES-cre)31Bsl/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pigatm1Bsl mutation (0 available); any Piga mutation (3 available)
Tg(FES-cre)31Bsl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
weight loss ( J:71354 )
• developing around 12 months of age

behavior/neurological
weakness ( J:71354 )
• general muscular weakness after 12 months of age
abnormal gait ( J:71354 )
• wide gait in males only, after 12 months of age
decreased locomotor activity ( J:71354 )
• decreased overall activity after 12 months of age

neoplasm
increased hemangioma incidence ( J:71354 )
• sometimes seen in spleen and lymph nodes at 12 months of age
increased B cell derived lymphoma incidence ( J:71354 )
• sometimes seen in spleen and lymph nodes at 12 months of age




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11/12/2024
MGI 6.24 		The Jackson Laboratory