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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hrastm1Mok
targeted mutation 1, Moyota Katsuki
MGI:2386128
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hrastm1Mok/Hrastm1Mok involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:3036357
cx2
 		Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Krastm1Mok
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)7Mok/0 		either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2) MGI:4361207
cx3
 		Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Krastm1Mok 		either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2) MGI:4361202
cx4
 		Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nrastm1Mok 		either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2) MGI:4361200
cx5
 		Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)2Jic/0 		involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2 MGI:4821332
cx6
 		Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
Tg(HRAS)2Jic/0 		involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2 MGI:4821330
cx7
 		Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nrastm1Mok 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4821331
cx8
 		Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Nrastm1Mok/Nras+ 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4821329
cx9
 		Hrastm1Mok/Hras+
Nrastm1Mok/Nrastm1Mok 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4821333
cx10
 		Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+ 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4821327
cx11
 		Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nras+ 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:4821328


Genotype
MGI:3036357
hm1
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased incidence of tumors by chemical induction ( J:62962 )
• a decreased susceptibility to DMBA induced skin papillomas was demonstrated
• no difference in spontaneous tumor formation was detected compared to wild-type mice

homeostasis/metabolism
chylous ascites ( J:159024 )
• 2 of 228 mice develop chylous ascites unlike wild-type mice
decreased incidence of tumors by chemical induction ( J:62962 )
• a decreased susceptibility to DMBA induced skin papillomas was demonstrated
• no difference in spontaneous tumor formation was detected compared to wild-type mice




Genotype
MGI:4361207
cx2
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Krastm1Mok
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)7Mok/0
Genetic
Background		 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Krastm1Mok mutation (6 available); any Kras mutation (84 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
Tg(HRAS)7Mok mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:135610 )
• born in expected numbers




Genotype
MGI:4361202
cx3
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Krastm1Mok
Genetic
Background		 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Krastm1Mok mutation (6 available); any Kras mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:135610 )
• development is normal to E9.5
• most are dead by E11.5
• none are found at E13.5




Genotype
MGI:4361200
cx4
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nrastm1Mok
Genetic
Background		 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:135610 )
• born in reduced numbers




Genotype
MGI:4821332
cx5
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nrastm1Mok
Tg(HRAS)2Jic/0
Genetic
Background		 involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
Tg(HRAS)2Jic mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:159024 )
N
• no mice exhibit chylous ascites




Genotype
MGI:4821330
cx6
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
Tg(HRAS)2Jic/0
Genetic
Background		 involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Krastm1Mok mutation (6 available); any Kras mutation (84 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
Tg(HRAS)2Jic mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:159024 )
N
• no mice exhibit chylous ascites




Genotype
MGI:4821331
cx7
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nrastm1Mok
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
chylous ascites ( J:159024 )
• 64 of 137 mice develop chylous ascites unlike wild-type mice




Genotype
MGI:4821329
cx8
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Nrastm1Mok/Nras+
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Krastm1Mok mutation (6 available); any Kras mutation (84 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
chylous ascites ( J:159024 )
• 35 of 37 mice develop chylous ascites unlike wild-type mice




Genotype
MGI:4821333
cx9
Allelic
Composition		 Hrastm1Mok/Hras+
Nrastm1Mok/Nrastm1Mok
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
chylous ascites ( J:159024 )
• 5 of 153 mice develop chylous ascites unlike wild-type mice




Genotype
MGI:4821327
cx10
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Krastm1Mok/Kras+
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Krastm1Mok mutation (6 available); any Kras mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
chylous ascites ( J:159024 )
• 20 of 135 mice develop chylous ascites unlike wild-type mice




Genotype
MGI:4821328
cx11
Allelic
Composition		 Hrastm1Mok/Hrastm1Mok
Nrastm1Mok/Nras+
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Mok mutation (15 available); any Hras mutation (30 available)
Nrastm1Mok mutation (7 available); any Nras mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
chylous ascites ( J:159024 )
• 2 of 175 mice develop chylous ascites unlike wild-type mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory