All Phenotypes Piga<tm1.1Tak> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Piga^tm1.1Tak
targeted mutation 1.1, Junji Takeda
MGI:2386158

Summary

2 genotypes

Allelic Composition	Piga^tm1.1Tak/Piga⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piga^tm1.1Tak mutation (0 available); any Piga mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• heterozygous females developed until E19, some lethality earlier depending on extent of X-inactivation

nervous system

abnormal brain development ( J:53967 )

exencephaly ( J:53967 )

craniofacial

craniofacial phenotype ( J:53967 )

• neural tube is open from anterior extremity of cranial region to hindbrain

• abnormalities are evident by E9.5

• the maxilla and mandibular bones were underdeveloped and did not fuse at the midline

• 77% of female embryos have cephalic region abnormalities

skeleton

• neural tube is open from anterior extremity of cranial region to hindbrain

• abnormalities are evident by E9.5

• the maxilla and mandibular bones were underdeveloped and did not fuse at the midline

• 77% of female embryos have cephalic region abnormalities

abnormal cartilage development ( J:53967 )

• abormal bending of limbs noted

Allelic Composition	Piga^tm1.1Tak/Y
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piga^tm1.1Tak mutation (0 available); any Piga mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• development of hemizygous males was disrupted after differentiation of the three germ layers and by E9

embryo

decreased embryo size ( J:53967 )

• mutants are 1/4 to 1/2 the size of normal littermates

• transparent appearance

growth/size/body

decreased embryo size ( J:53967 )

• mutants are 1/4 to 1/2 the size of normal littermates

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