Phenotypes associated with this allele

• Allele Symbol: Aff1^tm1Cim
• Allele Name: targeted mutation 1, Centre d'Immunologie de Marseille Luminy
• Allele ID: MGI:2386161
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aff1^tm1Cim/Aff1^tm1Cim	involves: 129P2/OlaHsd * BALB/c	MGI:3841424

Genotype
MGI:3841424

hm1

• Allelic Composition: Aff1^tm1Cim/Aff1^tm1Cim
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:63253 )

• death within 10 days in those mice showing the most extreme size reduction

growth/size/body

decreased body size ( J:63253 )

• about 20% are smaller than control litter mates

• size discrepancy disappears after 6 weeks unless it is particularly extreme

immune system

abnormal immune system cell morphology ( J:63253 )

abnormal T cell differentiation ( J:63253 )

• recovery from glucocorticoid depletion of DP cells is retarded

• T cell maturation is retarded

decreased double-positive T cell number ( J:63253 )

• double positive thymocyte numbers are significantly reduced

• double negative thymocyte numbers remain normal

decreased B cell number ( J:63253 )

• three fold reduction

decreased mature B cell number ( J:63253 )

• B220+,IgM(high) B cell numbers are reduced

decreased pre-B cell number ( J:63253 )

• B220+,CD43- pre B cells are reduced in number

• B220+,Cd43+ pro B cell numbers are normal

decreased single-positive T cell number ( J:63253 )

• continue to be present but in reduced numbers

abnormal immune system organ morphology ( J:63253 )

• peripheral lymph nodes colonized by thymocytes in appropriate proportions

thymus hypoplasia ( J:63253 )

• significantly reduced cellularity only when there is growth retardation

hematopoietic system

thymus hypoplasia ( J:63253 )

• significantly reduced cellularity only when there is growth retardation

abnormal T cell differentiation ( J:63253 )

• recovery from glucocorticoid depletion of DP cells is retarded

• T cell maturation is retarded

decreased double-positive T cell number ( J:63253 )

• double positive thymocyte numbers are significantly reduced

• double negative thymocyte numbers remain normal

decreased B cell number ( J:63253 )

• three fold reduction

decreased mature B cell number ( J:63253 )

• B220+,IgM(high) B cell numbers are reduced

decreased pre-B cell number ( J:63253 )

• B220+,CD43- pre B cells are reduced in number

• B220+,Cd43+ pro B cell numbers are normal

decreased single-positive T cell number ( J:63253 )

• continue to be present but in reduced numbers

endocrine/exocrine glands

thymus hypoplasia ( J:63253 )

• significantly reduced cellularity only when there is growth retardation