Phenotypes associated with this allele

• Allele Symbol: Col15a1^tm1Pih
• Allele Name: targeted mutation 1, Taina Pihlajaniemi
• Allele ID: MGI:2386162
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Col15a1^tm1Pih/Col15a1^tm1Pih	involves: 129S1/Sv * 129X1/SvJ	MGI:2664339

Genotype
MGI:2664339

hm1

• Allelic Composition: Col15a1^tm1Pih/Col15a1^tm1Pih
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Col15a1^tm1Pih/Col15a1^tm1Pih muscles display areas of degeneration, regeneration and variation in fiber size

muscle

abnormal muscle morphology ( J:67212 )

• 2/3 of mutants aged over 6 months show muscle abnormalities

• mutants are more vulnerable to exercise-induced muscle injury

abnormal muscle fiber morphology ( J:67212 )

• variable fiber size

enhanced skeletal muscle regeneration ( J:67212 )

• increased skeletal muscle regeneration

myopathy ( J:67212 )

• skeletal muscle exhibits focal changes characteristic of myopathic disorders, including the presence of degenerative fibers, regeneration, and variation in fiber size, with atrophic and split-muscle fibers starting at 13 weeks of age

• changes are more frequent in the back and paraspinal muscles than in other muscle groups

cardiovascular system

abnormal vascular endothelial cell morphology ( J:67212 )

• endothelial cell degeneration in the heart and skeletal muscle

abnormal capillary morphology ( J:67212 )

• some heart and skeletal muscle capillaries are irregular in shape, with intensively folded endothelial membranes

abnormal cardiovascular system physiology ( J:67212 )

• perfused hearts show a diminished inotropic response