Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mmp12tm1Sds targeted mutation 1, Steven D Shapiro MGI:2386174 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice fail to develop emphysema following a 6 month exposure to cigarette smoke unlike wild-type mice
• following a 6 month exposure to cigarette smoke, mice exhibit fewer macrophages in bronchoalveolar lavage samples compared to wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• macrophages have impaired capacity to degrade elastin and cannot penetrate reconstituted basement membranes in vitro and in vivo
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• have litter sizes only 60% that of wildtype
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• exhibit a decrease in the number of mature oligondendrocytes at P10, however no differences in oligodendrocyte precursor cell numbers
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• exhibit decreased myelination in the corpus callosum at P7 and P10, but not at P14, as evidenced by decreased MBP expression
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| N |
• mice exhibit normal susceptibility to induced aortic aneurysms
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• macrophages have impaired capacity to degrade elastin and cannot penetrate reconstituted basement membranes in vitro and in vivo
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• resistance to corneal infection is similar to Timp1 single homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• degree of lung inflammation was similar to that in single homozygous Itgb6 mutant mice
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| N |
• did not exhibit alveolar enlargement and did not develop emphysema
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• degree of lung inflammation was similar to that in single homozygous Itgb6 mutant mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| NOT | pulmonary emphysema | DOID:9675 |
OMIM:130700 |
J:89578 |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• as in Sftpdtm1Jhf, mice exhibit enlarged alveolar spaces compared with wild-type mice with foamy macrophage and lymphocyte infiltrates
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• exhibit a decrease in the number of mature oligondendrocytes at P10, however no differences in oligodendrocyte precursor cell numbers
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• exhibit a similar decrease in myelination in the corpus callosum at P7 and P10, but not at P14, as single homozygous mutants
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• following induction of aortic aneurysm with elastase, mice develop fewer aneurysms with less of an increase in aortic diameter compared with similarly treated wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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