Phenotypes associated with this allele

• Allele Symbol: Igfals^tm1Yrb
• Allele Name: targeted mutation 1, Yves R Boisclair
• Allele ID: MGI:2386180
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igfals^tm1Yrb/Igfals^tm1Yrb	involves: 129S4/SvJae * BALB/c	MGI:3603643
hm2	Igfals^tm1Yrb/Igfals^tm1Yrb	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N	MGI:3603644
cn3	Igf1^tm1Dlr/Igf1^tm1Dlr Igfals^tm1Yrb/Igfals^tm1Yrb Tg(Alb1-cre)1Dlr/?	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N	MGI:3603650

Genotype
MGI:3603643

hm1

• Allelic Composition: Igfals^tm1Yrb/Igfals^tm1Yrb
• Genetic Background: involves: 129S4/SvJae * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:62710 )

• body weight normal from birth to 14 days of age

• lighter weight by 15 days of age becoming significant by age 21 days

• maximum weight difference was 13% at age 70 days

reproductive system

decreased litter size ( J:62710 )

• litter sizes were slightly reduced

• nurturing behavior of mothers was normal otherwise

Genotype
MGI:3603644

hm2

• Allelic Composition: Igfals^tm1Yrb/Igfals^tm1Yrb
• Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

skeleton

abnormal femur morphology ( J:79109 )

• reduced cortical bone thickness

• 24% reduction in cortical bone volume and reduced trabecular bone volume

decreased diameter of femur ( J:79109 )

short femur ( J:79109 )

• by 7.5%

limbs/digits/tail

abnormal femur morphology ( J:79109 )

• reduced cortical bone thickness

• 24% reduction in cortical bone volume and reduced trabecular bone volume

decreased diameter of femur ( J:79109 )

short femur ( J:79109 )

• by 7.5%

Genotype
MGI:3603650

cn3

• Allelic Composition: Igf1^tm1Dlr/Igf1^tm1Dlr; Igfals^tm1Yrb/Igfals^tm1Yrb; Tg(Alb1-cre)1Dlr/?
• Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Igf1^tm1Dlr/Igf1^tm1Dlr Igfals^tm1Yrb/Igfals^tm1Yrb Tg(Alb1-cre)1Dlr/? mice exhibit reduced growth plate height

growth/size/body

decreased body length ( J:79109 )

• 30% reduction in total length by 2-3 weeks of age

skeleton

abnormal limb bone morphology ( J:79109 )

abnormal femur morphology ( J:79109 )

• reduced cortical bone thickness

• reduced trabecular bone volume and trabecular bone density

decreased diameter of femur ( J:79109 )

short femur ( J:79109 )

• 20% shorter at 21 days of age and 12% shorter at 6 weeks of age

abnormal long bone epiphyseal plate proliferative zone ( J:79109 )

• reduced 15 %

decreased width of hypertrophic chondrocyte zone ( J:79109 )

• reduced 26%

decreased long bone epiphyseal plate size ( J:79109 )

• tibial growth plate height reduced by 20%

• germinal zone height increased in the tibia

limbs/digits/tail

abnormal limb bone morphology ( J:79109 )

abnormal femur morphology ( J:79109 )

• reduced cortical bone thickness

• reduced trabecular bone volume and trabecular bone density

decreased diameter of femur ( J:79109 )

short femur ( J:79109 )

• 20% shorter at 21 days of age and 12% shorter at 6 weeks of age