mortality/aging
• die around E9.5
|
growth/size/body
• smaller at E7.5, especially in the anterior region
|
embryo
• dense cell accumulation in the primitive streak indicates the initiation of gastrulation and the ingression of ectodermal cells into the primitive streak, but the mesodermal cells are unable to depart from the primitive streak
|
• embryonic ectoderm expresses only anterior neuronal markers at E9.5
|
• marker analysis indicates a lack of active migration of the definitive endoderm
|
• analysis of molecular markers indicates a lack of the cranio-cardiac and paraxial mesoderm, however the axial mesoderm is initially generated but anterior extension is halted after E8.5
|
• smaller at E7.5, especially in the anterior region
|
• lack of paraxial mesoderm
|
• lack the mesodermal layer between the endoderm and ectoderm at E7.5
|
• abnormal accumulation of cells in the primitive streak indicates an inability of mesodermal cells to migrate out of the streak
|
• do not develop somites
|
cardiovascular system
• develop endothelial cells indicating that the initiation of vasculogenesis occurs, however no distinct blood vessels are seen
|
absent heart
(
J:62984
)
• do not develop a heart
|