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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mesp1/Mesp2tm1Ysa
targeted mutation 1, Yumiko Saga
MGI:2386200
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa involves: C57BL/6 * CBA * ICR MGI:3702328
cx2
 		Mesp1/Mesp2tm1Ysa/Mesp1+
Mesp1/Mesp2tm1Ysa/Mesp2tm8Ysa 		involves: C57BL/6 * CBA * ICR MGI:3709547
cx3
 		Mesp1/Mesp2tm1Ysa/Mesp1+
Mesp1/Mesp2tm1Ysa/Mesp2tm9Ysa 		involves: C57BL/6 * CBA * ICR MGI:3709548
cx4
 		Mesp1/Mesp2tm1Ysa/Mesp1+
Mesp1/Mesp2tm1Ysa/Mesp2tm11Ysa 		involves: C57BL/6 * CBA * ICR MGI:3709549
cx5
 		Mesp1/Mesp2tm1Ysa/Mesp1+
Mesp1/Mesp2tm1Ysa/Mesp2tm10Ysa 		involves: C57BL/6 * CBA * ICR MGI:3709550


Genotype
MGI:3702328
hm1
Allelic
Composition		 Mesp1/Mesp2tm1Ysa/Mesp1/Mesp2tm1Ysa
Genetic
Background		 involves: C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1/Mesp2tm1Ysa mutation (2 available); any Mesp1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
decreased embryo size ( J:62984 )
• smaller at E7.5, especially in the anterior region

embryo
abnormal gastrulation ( J:62984 )
• dense cell accumulation in the primitive streak indicates the initiation of gastrulation and the ingression of ectodermal cells into the primitive streak, but the mesodermal cells are unable to depart from the primitive streak
abnormal ectoderm development ( J:62984 )
• embryonic ectoderm expresses only anterior neuronal markers at E9.5
abnormal endoderm development ( J:62984 )
• marker analysis indicates a lack of active migration of the definitive endoderm
abnormal mesoderm development ( J:62984 )
• analysis of molecular markers indicates a lack of the cranio-cardiac and paraxial mesoderm, however the axial mesoderm is initially generated but anterior extension is halted after E8.5
decreased embryo size ( J:62984 )
• smaller at E7.5, especially in the anterior region
absent paraxial mesoderm ( J:62984 )
• lack of paraxial mesoderm
absent mesoderm ( J:62984 )
• lack the mesodermal layer between the endoderm and ectoderm at E7.5
abnormal primitive streak formation ( J:62984 )
• abnormal accumulation of cells in the primitive streak indicates an inability of mesodermal cells to migrate out of the streak
absent somites ( J:62984 )
• do not develop somites

cardiovascular system
abnormal blood vessel morphology ( J:62984 )
• develop endothelial cells indicating that the initiation of vasculogenesis occurs, however no distinct blood vessels are seen
absent heart ( J:62984 )
• do not develop a heart




Genotype
MGI:3709547
cx2
Allelic
Composition		 Mesp1/Mesp2tm1Ysa/Mesp1+
Mesp1/Mesp2tm1Ysa/Mesp2tm8Ysa
Genetic
Background		 involves: C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1/Mesp2tm1Ysa mutation (2 available); any Mesp1 mutation (18 available)
Mesp1/Mesp2tm1Ysa mutation (0 available); any Mesp2 mutation (30 available)
Mesp2tm8Ysa mutation (1 available); any Mesp2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
rib fusion ( J:119678 )
• at E17.5, 6.5 ribs are fused in 2 of 2 mice




Genotype
MGI:3709548
cx3
Allelic
Composition		 Mesp1/Mesp2tm1Ysa/Mesp1+
Mesp1/Mesp2tm1Ysa/Mesp2tm9Ysa
Genetic
Background		 involves: C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1/Mesp2tm1Ysa mutation (2 available); any Mesp1 mutation (18 available)
Mesp1/Mesp2tm1Ysa mutation (0 available); any Mesp2 mutation (30 available)
Mesp2tm9Ysa mutation (1 available); any Mesp2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
rib fusion ( J:119678 )
• at E17.5, 16 ribs are fused in 3 of 3 mice




Genotype
MGI:3709549
cx4
Allelic
Composition		 Mesp1/Mesp2tm1Ysa/Mesp1+
Mesp1/Mesp2tm1Ysa/Mesp2tm11Ysa
Genetic
Background		 involves: C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1/Mesp2tm1Ysa mutation (2 available); any Mesp1 mutation (18 available)
Mesp1/Mesp2tm1Ysa mutation (0 available); any Mesp2 mutation (30 available)
Mesp2tm11Ysa mutation (0 available); any Mesp2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal vertebrae morphology ( J:119678 )
• caudal vertebra are malformed and a posterior expansion of defects is seen
vertebral fusion ( J:119678 )
• more severe fusion of vertebra than in mice containing Mesp2 disruptions pedicles are fused




Genotype
MGI:3709550
cx5
Allelic
Composition		 Mesp1/Mesp2tm1Ysa/Mesp1+
Mesp1/Mesp2tm1Ysa/Mesp2tm10Ysa
Genetic
Background		 involves: C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1/Mesp2tm1Ysa mutation (2 available); any Mesp1 mutation (18 available)
Mesp1/Mesp2tm1Ysa mutation (0 available); any Mesp2 mutation (30 available)
Mesp2tm10Ysa mutation (1 available); any Mesp2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body length ( J:119678 )
• shortening of the trunk region

skeleton
abnormal vertebrae morphology ( J:119678 )
• severe truncation of the vertebra
fusion of vertebral arches ( J:119678 )
• severe fusion




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory