Phenotypes associated with this allele

• Allele Symbol: Ogg1^tm1Tno
• Allele Name: targeted mutation 1, Tetsuo Noda
• Allele ID: MGI:2386212
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ogg1^tm1Tno/Ogg1^tm1Tno	involves: 129S4/SvJae * C57BL/6J	MGI:3783753
cx2	Ogg1^tm1Tno/Ogg1^tm1Tno Tg(gptdelta)1Nmi/0	involves: 129S4/SvJae * C57BL/6J	MGI:3783754

Genotype
MGI:3783753

hm1

• Allelic Composition: Ogg1^tm1Tno/Ogg1^tm1Tno
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal DNA repair ( J:61684 , J:84649 )

• nicking activity toward substrate DNA with 8-OH-G-C pairs is strongly attenuated compared to controls (J:61684)

• mutants exhibit marked accumulation (4.2-fold vs wild-type) of 8-OH-G in their DNA at 9 weeks of age (J:61684)

• mutants treated with renal mutagen and carcinogen KBrO₃ exhibit marked accumulation (26-fold vs treated wild-type) of 8-OH-G in liver DNA between 4 and 12 weeks (J:84649)

• after stopping treatment, levels of 8-OH-G do not decrease as observed in treated controls (J:84649)

homeostasis/metabolism

abnormal DNA repair ( J:61684 , J:84649 )

• nicking activity toward substrate DNA with 8-OH-G-C pairs is strongly attenuated compared to controls (J:61684)

• mutants exhibit marked accumulation (4.2-fold vs wild-type) of 8-OH-G in their DNA at 9 weeks of age (J:61684)

• mutants treated with renal mutagen and carcinogen KBrO₃ exhibit marked accumulation (26-fold vs treated wild-type) of 8-OH-G in liver DNA between 4 and 12 weeks (J:84649)

• after stopping treatment, levels of 8-OH-G do not decrease as observed in treated controls (J:84649)

liver/biliary system

liver/biliary system phenotype ( J:84649 )

N • male mutants treated with KBrO₃ show equivalent cell proliferation and regeneration to wild-type controls with partial hepatectomy 1 week after treatment stoppageJ

Genotype
MGI:3783754

cx2

• Allelic Composition: Ogg1^tm1Tno/Ogg1^tm1Tno; Tg(gptdelta)1Nmi/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

cellular

abnormal cell physiology ( J:61684 , J:84649 )

• liver DNA from double mutants exhibits more than a 2-fold elevation in spontaneous mutations (single base substitutions) compared to Ogg1-sufficient gpt hemizygotes (J:61684)

• mutation frequency is higher than in Ogg1-wild-type transgenic animals; frequency tends to increase after liver regeneration following partial hepatectomy (J:84649)

• spectrum of mutations in cultured mutant liver cells shows an increase in number transverions (GC->AT) and number of deletion mutations is increased during liver regeneration (J:84649)