Analysis Tools
mortality/aging
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• although offspring of heterozygous parents exhibit an increase in lethality regardless of genotype, there is a preferential loss of homozygotes
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growth/size/body
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• males and females are, respectively, 56% and 77% the weight of wild-type males and females
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cardiovascular system
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• myocardial wall at the distal portion of the right ventricle displays haphazard trabeculae that forms abnormal spaces
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• the contour of the right ventricular outlet around the pulmonary valve bulges outwards
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• myocardial wall at the distal portion of the right ventricle is composed of a thin, irregular, compact layer and haphazard trabeculae forming abnormal spaces
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• polymorphic non-sustained ventricular tachycardia can be induced in one homozygote
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• 1 of 9 exhibits atrioventricular dissociations, however ventricular conductance is normal in homozygotes
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reproductive system
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• secondary spermatogonia and further differentiated stages of spermatogenesis are completely absent
• primary spermatogonia are severely reduced in number
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• show all stages of follicular maturation but at reduced numbers
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• most of the lumen of seminiferous tubules is occupied by Sertoli cells
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• testis is more hypotrophic compared to other organs, reaching less than 20% of the testis weight (relative to body weight) of controls
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• only 2 of 7 homozygous females gave birth to single fully developed pups that were born dead, however do not exhibit germ-cell deficiency
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vision/eye
endocrine/exocrine glands
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• show all stages of follicular maturation but at reduced numbers
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• most of the lumen of seminiferous tubules is occupied by Sertoli cells
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• testis is more hypotrophic compared to other organs, reaching less than 20% of the testis weight (relative to body weight) of controls
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muscle
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• myocardial wall at the distal portion of the right ventricle displays haphazard trabeculae that forms abnormal spaces
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cellular
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• secondary spermatogonia and further differentiated stages of spermatogenesis are completely absent
• primary spermatogonia are severely reduced in number
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