Analysis Tools
mortality/aging
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• 40% die between birth and 21 days of age, with most lost 5 days after birth
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cellular
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• secondary spermatogonia and further differentiated stages of spermatogenesis are completely absent
• primary spermatogonia are severely reduced in number
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growth/size/body
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• some neonates exhibit a mild heart hypertrophy, however the heart ventricles are normal and do not exhibit any other heart morphology abnormalities
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• males and females are, respectively, 69% and 73% the weight of wild-type males and females
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cardiovascular system
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• some neonates exhibit a mild heart hypertrophy, however the heart ventricles are normal and do not exhibit any other heart morphology abnormalities
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• 10 of 12 exhibit spontaneous singular premature ventricular beats, however ventricular conductance is normal
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reproductive system
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• secondary spermatogonia and further differentiated stages of spermatogenesis are completely absent
• primary spermatogonia are severely reduced in number
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• show all stages of follicular maturation but at reduced numbers
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• most of the lumen of seminiferous tubules is occupied by Sertoli cells
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• testis is more hypotrophic compared to other organs, reaching less than 20% of the testis weight (relative to body weight) of controls
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• no homozygous females show signs of pregnancy or delivered litters, however do not exhibit germ-cell deficiency
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endocrine/exocrine glands
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• show all stages of follicular maturation but at reduced numbers
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• most of the lumen of seminiferous tubules is occupied by Sertoli cells
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• testis is more hypotrophic compared to other organs, reaching less than 20% of the testis weight (relative to body weight) of controls
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vision/eye
| N |
• do not develop cataracts
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