Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mmp3tm1Mrl targeted mutation 1, Merck Research Laboratory MGI:2386262 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• slower healing of excisional wounds although incisional wounds healed normally
• wound area initially increases then heals very slowly (5-10%/day vs 50%/day normally) in a concentric fashion
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced infiltration into colon
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• delayed clearance of Citrobacter rodentium from colon after oral infection, 35 days as opposed to 21 days
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• increased area on endplates with acetylcholine receptors
• endplates significantly larger than normal from day 6 onward
• increased numbers of junctional folds on endplates, some in atypical locations
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• miniature endplate potentials rise more slowly than normal
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• reduced infiltration into colon
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• presence of inflammatory cells in joints
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• incidence and severity of collagen induced arthritis greater than controls at day 16, equivalent to level induced in B10.RII mice
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• erosion of articular cartilage
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• presence of inflammatory cells in joints
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• incidence and severity of collagen induced arthritis greater than controls at day 16, equivalent to level induced in B10.RII mice
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• erosion of articular cartilage
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following IgG-induction of acute lung injury, mice exhibit reduced lung injury, decreased BALF protein leakage, and perivascular edema with reduced neutrophils and macrophages recruitment compared with similarly treated wild-type mice
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| N |
• macrophage resorption of co-cultured intervertebral discs, migration, and chemotaxis are normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• DNFB-sensitized and challenged mice exhibit minimal proliferation of lymphocyte in draining lymph nodes unlike similarly treated wild-type mice
• however, lymphocyte proliferation in response to Con A is normal
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• DNFB-sensitized and challenged mice exhibit reduced contact hypersensitivity driven ear swelling compared with similarly treated wild-type mice
• however, irritant initiated, chemically-induced inflammation to phenol is normal
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• DNFB-sensitized and challenged mice exhibit minimal proliferation of lymphocyte in draining lymph nodes unlike similarly treated wild-type mice
• however, lymphocyte proliferation in response to Con A is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after infection, inflammation is resolved and corneal integrity restored unlike in C57BL/6 wild-type mice, however resistance is decreased compared to Timp1 single homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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