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Allele Symbol Allele Name Allele ID |
Ptprz1tm1Schl targeted mutation 1, Joseph Schlessinger MGI:2386268 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit spontaneous osteosarcoma development at 18 months of age
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• mice exhibit spontaneous osteosarcoma development at 18 months of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• an increased incidence of apoptosis of mature oligodendrocytes was observed in EAE
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• in experimental autoimmune encephalitis (EAE), mutant mice exhibit an impaired ability to recover from demyelinating lesions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ex vivo, osteosarcoma-derived cell lines exhibit increased proliferation in BrdU incorporation assays, a higher abundance of tyrosine-phosphorylated proteins, and no cellular growth in response to long-term administration of Mdk (midkine, a heparin-binding growth factor known to antagonize Ptprz1 in other cell types)
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• at 52 weeks of age, 7 of 38 (~19%) mice exhibit osteosarcoma development by contact X-ray analysis
• skeletal tumors are found in three different locations i.e., ribs, spine or long bones, but not in craniofacial bones, and consist of mineralized tissue
• undecalcified histology showed that tumors represent bony tissue with osteocytes embedded into mineralized matrix, confirming their osteosarcoma nature
• cell lines derived from tumors and cultured in the presence of ascorbic acid and beta-glycerophosphate are able to form a mineralized matrix and show differential expression of osteoblast differentiation markers
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• at 52 weeks of age, 7 of 38 (~19%) mice exhibit osteosarcoma development by contact X-ray analysis
• skeletal tumors are found in three different locations i.e., ribs, spine or long bones, but not in craniofacial bones, and consist of mineralized tissue
• undecalcified histology showed that tumors represent bony tissue with osteocytes embedded into mineralized matrix, confirming their osteosarcoma nature
• cell lines derived from tumors and cultured in the presence of ascorbic acid and beta-glycerophosphate are able to form a mineralized matrix and show differential expression of osteoblast differentiation markers
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at 52 weeks of age, 2 of 38 (~5%) mice exhibit visible skeletal tumors by contact X-ray analysis
• skeletal tumors are found in three different locations i.e., ribs, spine or long bones, but not in craniofacial bones, and consist of mineralized tissue
• cell lines derived from tumors and cultured in the presence of ascorbic acid and beta-glycerophosphate are able to form a mineralized matrix and show differential expression of osteoblast differentiation markers, confirming their osteosarcoma nature
|
|
• at 52 weeks of age, 2 of 38 (~5%) mice exhibit visible skeletal tumors by contact X-ray analysis
• skeletal tumors are found in three different locations i.e., ribs, spine or long bones, but not in craniofacial bones, and consist of mineralized tissue
• cell lines derived from tumors and cultured in the presence of ascorbic acid and beta-glycerophosphate are able to form a mineralized matrix and show differential expression of osteoblast differentiation markers, confirming their osteosarcoma nature
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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