All Phenotypes Tyrobp<tm1Lll> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tyrobp^tm1Lll/Tyrobp^tm1Lll	B6.129P2-Tyrobp^tm1Lll	MGI:3843527
hm2	Tyrobp^tm1Lll/Tyrobp^tm1Lll	involves: 129P2/OlaHsd	MGI:4441171
hm3	Tyrobp^tm1Lll/Tyrobp^tm1Lll	involves: 129P2/OlaHsd * C57BL/6	MGI:3818493
cx4	Hcst^tm1.1Cln/Hcst^tm1.1Cln Tyrobp^tm1Lll/Tyrobp^tm1Lll	B6.Cg-Hcst^tm1.1Cln Tyrobp^tm1Lll	MGI:3843528
cx5	Fcer1g^tm1Rav/Fcer1g^tm1Rav Tyrobp^tm1Lll/Tyrobp^tm1Lll	involves: 129P2/OlaHsd	MGI:3840591
cx6	Fcer1g^tm1Rav/Fcer1g^tm1Rav Tyrobp^tm1Lll/Tyrobp^tm1Lll	involves: 129P2/OlaHsd * C57BL/6	MGI:3818498

Allelic Composition	Tyrobp^tm1Lll/Tyrobp^tm1Lll
Genetic Background	B6.129P2-Tyrobp^tm1Lll

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrobp^tm1Lll mutation (1 available); any Tyrobp mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK T cell physiology ( J:147867 )

• NK cells infected with mouse cytomegalovirus undergo less proliferation than in similarly treated wild-type cells

decreased interferon-gamma secretion ( J:147867 )

• antibody cross-linking of the Klra8 (Ly49H) receptor in cultured NK cells fails to induce IFNgamma secretion unlike in similarly treated wild-type cells

hematopoietic system

abnormal NK T cell physiology ( J:147867 )

• NK cells infected with mouse cytomegalovirus undergo less proliferation than in similarly treated wild-type cells

Allelic Composition	Tyrobp^tm1Lll/Tyrobp^tm1Lll
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrobp^tm1Lll mutation (1 available); any Tyrobp mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to induced arthritis ( J:158811 )

• the incidence and severity of collagen antibody-induced arthritis are decreased compared to in similarly treated wild-type mice

skeleton

decreased susceptibility to induced arthritis ( J:158811 )

• the incidence and severity of collagen antibody-induced arthritis are decreased compared to in similarly treated wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:64763 )

N	• myeloid cell function in vitro is normal

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or coculture with wild-type osteoblasts can partially restore differentiation

decreased T cell proliferation ( J:64763 )

• in vitro, T cell proliferation response to immunization with MOG is 50% less than in similarly treated heterozygous cells used as a control

increased dendritic cell number ( J:64763 )

• in the skin

impaired natural killer cell mediated cytotoxicity ( J:64763 )

• NK cells exposed to Ly49D antibody exhibit decreased lytic activity towards FcR+ cells compared to similarly treated heterozygous cells used as a control

• NK cell lysis of CHO cells is impaired Ly49D receptor-dependent compared to for heterozygous cells used as a control

• however, lytic activity towards tumor cell lines YAC-1, IC-21, J774, RMA/S, AK7 and AK40 is normal

increased natural killer cell mediated cytotoxicity ( J:64763 )

• NK cells exhibit increased natural lytic activity towards FcR+ target cells compared to heterozygous cells used as a control

decreased interferon-gamma secretion ( J:64763 )

• in vitro, T cells stimulated with MOG do not produce IFN-gamma unlike heterozygous cells used as a control

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:64763 )

• following treatment with MOG, Freund's adjuvant and pertussis toxin, 30% of mice are completely resistant to the development of experimental autoimmune encephalomyelitis and the remaining mice exhibit reduced disease severity compared to similarly treated heterozygotes used as a control

• mice immunized with MOG exhibit reduced accumulation of leukocytes, macrophages and activated microglial cells compared to in similarly treated heterozygotes used as a control

• Background Sensitivity: female mice are somewhat more susceptible to development of experimental autoimmune encephalomyelitis than male mice likely due to the genetic background

skeleton

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or coculture with wild-type osteoblasts can partially restore differentiation

osteopetrosis ( J:89583 )

decreased bone resorption ( J:89583 )

• osteoclast fail to resorb mineralized matrix in vivo unlike wild-type cells

• treatment of osteoclast precursors with large doses of macrophage colony stimulating factor does not rescue bone resoprtion

• however, coculture of osteoclast precursors with wild-type osteoblasts partially restores osteaoclasts bone resorption

hematopoietic system

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or coculture with wild-type osteoblasts can partially restore differentiation

decreased T cell proliferation ( J:64763 )

• in vitro, T cell proliferation response to immunization with MOG is 50% less than in similarly treated heterozygous cells used as a control

increased dendritic cell number ( J:64763 )

• in the skin

impaired natural killer cell mediated cytotoxicity ( J:64763 )

• NK cells exposed to Ly49D antibody exhibit decreased lytic activity towards FcR+ cells compared to similarly treated heterozygous cells used as a control

• NK cell lysis of CHO cells is impaired Ly49D receptor-dependent compared to for heterozygous cells used as a control

• however, lytic activity towards tumor cell lines YAC-1, IC-21, J774, RMA/S, AK7 and AK40 is normal

increased natural killer cell mediated cytotoxicity ( J:64763 )

• NK cells exhibit increased natural lytic activity towards FcR+ target cells compared to heterozygous cells used as a control

cellular

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or coculture with wild-type osteoblasts can partially restore differentiation

decreased T cell proliferation ( J:64763 )

• in vitro, T cell proliferation response to immunization with MOG is 50% less than in similarly treated heterozygous cells used as a control

Allelic Composition	Hcst^tm1.1Cln/Hcst^tm1.1Cln Tyrobp^tm1Lll/Tyrobp^tm1Lll
Genetic Background	B6.Cg-Hcst^tm1.1Cln Tyrobp^tm1Lll

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcst^tm1.1Cln mutation (0 available); any Hcst mutation (9 available)
Tyrobp^tm1Lll mutation (1 available); any Tyrobp mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK T cell physiology ( J:147867 )

• NK cells fail to kill m157-expressing target cells unlike wild-type cells

abnormal response to infection ( J:147867 )

• 4 days after infection with mouse cytomegalovirus, mice exhibit higher titers than in similarly treated Tyrobp^tm1Lll homozygotes

hematopoietic system

abnormal NK T cell physiology ( J:147867 )

• NK cells fail to kill m157-expressing target cells unlike wild-type cells

Allelic Composition	Fcer1g^tm1Rav/Fcer1g^tm1Rav Tyrobp^tm1Lll/Tyrobp^tm1Lll
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1g^tm1Rav mutation (8 available); any Fcer1g mutation (26 available)
Tyrobp^tm1Lll mutation (1 available); any Tyrobp mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal osteoclast physiology ( J:147155 )

• fewer tartrate-resistant acid phosphatase (TRAP)+ osteoclasts are observed compared to in wild-type mice

skeleton

abnormal osteoclast physiology ( J:147155 )

• fewer tartrate-resistant acid phosphatase (TRAP)+ osteoclasts are observed compared to in wild-type mice

hematopoietic system

abnormal osteoclast physiology ( J:147155 )

• fewer tartrate-resistant acid phosphatase (TRAP)+ osteoclasts are observed compared to in wild-type mice

Allelic Composition	Fcer1g^tm1Rav/Fcer1g^tm1Rav Tyrobp^tm1Lll/Tyrobp^tm1Lll
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:89583 )

N	• unlike Src or Tnfsf11 mutants, mice develop teeth

short femur ( J:89583 )

increased diameter of femur ( J:89583 )

abnormal bone structure ( J:89583 )

• bones exhibit large areas of unresorbed bone with cartilaginous streaks unlike wild-type bone

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or transfection of osteaclast precursors with the Tyrobp immunoreceptor signaling motifs can partially restore differentiation

abnormal bone marrow cavity morphology ( J:89583 )

• small

abnormal trabecular bone morphology ( J:89583 )

• mice exhibit an increased in trabecular number, trabecular thickness and decreased trabecular separation compared to wild-type mice

• trabecular structures are concave and solid with tube-like channels of arrow space unlike in wild trabeculae that are rod-like

increased bone mass ( J:89583 )

osteopetrosis ( J:89583 )

• mice exhibit a severe increase in bone volume compared to in wild-type mice

decreased bone resorption ( J:89583 )

• osteoclast fail to resorb mineralized matrix in vivo unlike wild-type cells

• treatment of osteoclast precursors with large doses of macrophage colony stimulating factor does not rescue bone resoprtion

• however, transfection of osteaclast precursors with the Tyrobp immunoreceptor signaling motifs partially restores osteaoclasts bone resorption

growth/size/body

round face ( J:89583 )

• rounded face

decreased body size ( J:89583 )

craniofacial

round face ( J:89583 )

• rounded face

immune system

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

hematopoietic system

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

limbs/digits/tail

short femur ( J:89583 )

increased diameter of femur ( J:89583 )

cellular

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

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