Phenotypes associated with this allele

• Allele Symbol: Kat2b^tm1Roth
• Allele Name: targeted mutation 1, Sharon Y Roth
• Allele ID: MGI:2386280
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kat2b^tm1Roth/Kat2b^tm1Roth	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3801421
cx2	Kat2a^tm1Roth/Kat2a^tm1Roth Kat2b^tm1Roth/Kat2b^tm1Roth	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3801420

Genotype
MGI:3801421

hm1

• Allelic Composition: Kat2b^tm1Roth/Kat2b^tm1Roth
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:65002 )

• mice exhibit no obvious abnormal phenotype

Genotype
MGI:3801420

cx2

• Allelic Composition: Kat2a^tm1Roth/Kat2a^tm1Roth; Kat2b^tm1Roth/Kat2b^tm1Roth
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:65002 )

• mice die approximately at E7.5

embryo

embryonic growth retardation ( J:65002 )

abnormal embryonic tissue morphology ( J:65002 )

• at E6.5, mice are arrested at the egg cylinder stage with severely disorganized embryonic ectoderm and visceral endoderm

abnormal visceral yolk sac morphology ( J:65002 )

• some yolk sacs are filled with blood

growth/size/body

embryonic growth retardation ( J:65002 )