Analysis Tools|
Allele Symbol Allele Name Allele ID |
Slpitm1Smw targeted mutation 1, Sharon M Wahl MGI:2386293 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• activated platelets are unable to inhibit neutrophil elastase activity
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• activated platelets are unable to inhibit neutrophil elastase activity
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased levels of the active form of TGF-beta are found in wound areas
• non-stimulated macrophages produce significantly more of the active form of TGF-beta than controls
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• there are increased numbers of neutrophils and monocytes associated with skin wounds within the first 24 hours of injury
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• healing of full thickness dorsal incisions is significantly delayed in these mice
• wounds are still open 14 days after injury compared to wild-type mice that close their wounds within three days
• wound size is 9-fold greater 14 days after injury compared to controls
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• collagen matrix deposition associated with full thickness dorsal incisions is impaired
• reduced matrix deposition may be associated with the increased elastase activity that occurs in mutant wounds
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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