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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Igf1rtm1.1Mhz
targeted mutation 1.1, Martin Holzenberger
MGI:2386328
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Igf1rtm1.1Mhz/Igf1rtm1.1Mhz involves: 129/Sv * C57BL/6 * FVB/N MGI:3775300
cn2
Igf1rtm1.1Mhz/Igf1r+
Insrtm1Khn/Insrtm1Khn
Tg(Ckmm-cre)5Khn/0
involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB MGI:3775310
cn3
Igf1rtm1.1Mhz/Igf1rtm1.1Mhz
Insrtm1Khn/Insrtm1Khn
Tg(Ckmm-cre)5Khn/0
involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB MGI:3775311
cn4
Igf1rtm1.1Mhz/Igf1rtm1.1Mhz
Insrtm1Khn/Insr+
Tg(Ckmm-cre)5Khn/0
involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB MGI:3775313
cn5
Igf1rtm1.1Mhz/Igf1rtm1.1Mhz
Tg(Ins2-cre)25Mgn/0
involves: 129/Sv * C57BL/6 * DBA/2 MGI:3775384
cn6
Igf1rtm1.1Mhz/Igf1rtm1.1Mhz
Tg(Ckmm-cre)5Khn/0
involves: 129/Sv * C57BL/6 * FVB MGI:3775312
cx7
Igf1rtm1.1Mhz/Igf1rtm1.1Mhz
Insrtm1Khn/Insrtm1Khn
involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB MGI:3775314


Genotype
MGI:3775300
hm1
Allelic
Composition
Igf1rtm1.1Mhz/Igf1rtm1.1Mhz
Genetic
Background
involves: 129/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1.1Mhz mutation (0 available); any Igf1r mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• mice exhibit normal growth rates




Genotype
MGI:3775310
cn2
Allelic
Composition
Igf1rtm1.1Mhz/Igf1r+
Insrtm1Khn/Insrtm1Khn
Tg(Ckmm-cre)5Khn/0
Genetic
Background
involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1.1Mhz mutation (0 available); any Igf1r mutation (88 available)
Insrtm1Khn mutation (1 available); any Insr mutation (95 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 3 of 13 mice die by 6 months of age

cardiovascular system
• at P17, left ventricular fractional shortening is reduced 23% compared to Igf1rtm1.1Mhz Insrtm1Khn homozygote controls

respiratory system
• beginning at 3 months of age, 1 of 13 mice appear to gasp for air

behavior/neurological
• beginning at 3 months of age, 1 of 13 mice exhibit less activity than wild-type mice

muscle
• at P17, left ventricular fractional shortening is reduced 23% compared to Igf1rtm1.1Mhz Insrtm1Khn homozygote controls

homeostasis/metabolism
N
• mice exhibit normal glucose homeostasis




Genotype
MGI:3775311
cn3
Allelic
Composition
Igf1rtm1.1Mhz/Igf1rtm1.1Mhz
Insrtm1Khn/Insrtm1Khn
Tg(Ckmm-cre)5Khn/0
Genetic
Background
involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1.1Mhz mutation (0 available); any Igf1r mutation (88 available)
Insrtm1Khn mutation (1 available); any Insr mutation (95 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within the first month usually after birth 2 days after beginning to gasp for air at P16
• death is either spontaneous or precipitated by the stress of routine handling

cardiovascular system
• mice exhibit irregular and disrupted sarcomeric Z and M lines and increased mitochondria with central crowding compared to wild-type hearts
• at P8 and P20, heart weights reduced 15% and 25%, respectively, compared to in wild-type mice
• mice exhibit decreased heart weight to body weight
• at P17, mice exhibit an increase in left ventricle diameter of 6.7% in diastolic and 57.1% in systolic states
• at P17, left ventricular fractional shortening is reduced 33% compared to Igf1rtm1.1Mhz Insrtm1Khn homozygote controls

behavior/neurological
• at P16, mice become less active than wild-type mice

respiratory system
• at P16, mice gasp for air

growth/size/body
• at P20, mice weigh 15% to 20% less than wild-type mice
• despite normal growth rates during the first two weeks after birth, mice exhibit reduced growth rates during week 3

muscle
• mice exhibit irregular and disrupted sarcomeric Z and M lines and increased mitochondria with central crowding compared to wild-type hearts
• at P17, left ventricular fractional shortening is reduced 33% compared to Igf1rtm1.1Mhz Insrtm1Khn homozygote controls

homeostasis/metabolism
N
• mice exhibit normal glucose homeostasis

cellular




Genotype
MGI:3775313
cn4
Allelic
Composition
Igf1rtm1.1Mhz/Igf1rtm1.1Mhz
Insrtm1Khn/Insr+
Tg(Ckmm-cre)5Khn/0
Genetic
Background
involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1.1Mhz mutation (0 available); any Igf1r mutation (88 available)
Insrtm1Khn mutation (1 available); any Insr mutation (95 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• heart function and morphology is normal

growth/size/body
N
• mice exhibit normal growth rates

homeostasis/metabolism
N
• mice exhibit normal glucose homeostasis




Genotype
MGI:3775384
cn5
Allelic
Composition
Igf1rtm1.1Mhz/Igf1rtm1.1Mhz
Tg(Ins2-cre)25Mgn/0
Genetic
Background
involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1.1Mhz mutation (0 available); any Igf1r mutation (88 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice do not exhibit an increase in mortality when fed a high fat diet

homeostasis/metabolism
• mild on a high fat diet
• on a high fat diet

digestive/alimentary system
N
• when fed a high fat diet mice are capable of manifesting compensatory islet hyperplasia as in wild-type mice




Genotype
MGI:3775312
cn6
Allelic
Composition
Igf1rtm1.1Mhz/Igf1rtm1.1Mhz
Tg(Ckmm-cre)5Khn/0
Genetic
Background
involves: 129/Sv * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1.1Mhz mutation (0 available); any Igf1r mutation (88 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice exhibit increased heart weight
• however, heart function is normal

growth/size/body
N
• mice exhibit normal growth rates
• mice exhibit increased heart weight
• however, heart function is normal

homeostasis/metabolism
N
• mice exhibit normal glucose homeostasis




Genotype
MGI:3775314
cx7
Allelic
Composition
Igf1rtm1.1Mhz/Igf1rtm1.1Mhz
Insrtm1Khn/Insrtm1Khn
Genetic
Background
involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1rtm1.1Mhz mutation (0 available); any Igf1r mutation (88 available)
Insrtm1Khn mutation (1 available); any Insr mutation (95 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• heart function and morphology is normal

growth/size/body
N
• mice exhibit normal growth rates

homeostasis/metabolism
N
• mice exhibit normal glucose homeostasis





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory