Analysis Tools|
Allele Symbol Allele Name Allele ID |
Igf1rtm1.1Mhz targeted mutation 1.1, Martin Holzenberger MGI:2386328 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 3 of 13 mice die by 6 months of age
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• at P17, left ventricular fractional shortening is reduced 23% compared to Igf1rtm1.1Mhz Insrtm1Khn homozygote controls
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• beginning at 3 months of age, 1 of 13 mice appear to gasp for air
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• beginning at 3 months of age, 1 of 13 mice exhibit less activity than wild-type mice
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• at P17, left ventricular fractional shortening is reduced 23% compared to Igf1rtm1.1Mhz Insrtm1Khn homozygote controls
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| N |
• mice exhibit normal glucose homeostasis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die within the first month usually after birth 2 days after beginning to gasp for air at P16
• death is either spontaneous or precipitated by the stress of routine handling
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• mice exhibit irregular and disrupted sarcomeric Z and M lines and increased mitochondria with central crowding compared to wild-type hearts
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• thin at P17
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• at P8 and P20, heart weights reduced 15% and 25%, respectively, compared to in wild-type mice
• mice exhibit decreased heart weight to body weight
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• at P17, mice exhibit an increase in left ventricle diameter of 6.7% in diastolic and 57.1% in systolic states
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• at P17
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• at P17
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• at P17, left ventricular fractional shortening is reduced 33% compared to Igf1rtm1.1Mhz Insrtm1Khn homozygote controls
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• at P16, mice become less active than wild-type mice
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• at P16, mice gasp for air
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• at P20, mice weigh 15% to 20% less than wild-type mice
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• despite normal growth rates during the first two weeks after birth, mice exhibit reduced growth rates during week 3
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• mice exhibit irregular and disrupted sarcomeric Z and M lines and increased mitochondria with central crowding compared to wild-type hearts
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• at P17
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• at P17, left ventricular fractional shortening is reduced 33% compared to Igf1rtm1.1Mhz Insrtm1Khn homozygote controls
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| N |
• mice exhibit normal glucose homeostasis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• heart function and morphology is normal
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| N |
• mice exhibit normal growth rates
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| N |
• mice exhibit normal glucose homeostasis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice do not exhibit an increase in mortality when fed a high fat diet
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• mild on a high fat diet
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• on a high fat diet
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| N |
• when fed a high fat diet mice are capable of manifesting compensatory islet hyperplasia as in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit increased heart weight
• however, heart function is normal
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| N |
• mice exhibit normal growth rates
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• mice exhibit increased heart weight
• however, heart function is normal
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| N |
• mice exhibit normal glucose homeostasis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• heart function and morphology is normal
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| N |
• mice exhibit normal growth rates
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| N |
• mice exhibit normal glucose homeostasis
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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