All Phenotypes Igf1r<tm1.2Mhz> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igf1r^tm1.2Mhz
targeted mutation 1.2, Martin Holzenberger
MGI:2386329

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igf1r^tm1.2Mhz/Igf1r^tm1.2Mhz	involves: 129/Sv * C57BL/6 * FVB/N	MGI:3775301
cx2	Igf1r^tm1.2Mhz/Igf1r⁺ Zfand2b^tm1Otin/Zfand2b^tm1Otin	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6	MGI:6784094

Allelic Composition	Igf1r^tm1.2Mhz/Igf1r^tm1.2Mhz
Genetic Background	involves: 129/Sv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1.2Mhz mutation (1 available); any Igf1r mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:63460 )

• at birth mice cannot breath and die within the first few minutes of life

respiratory system

respiratory failure ( J:63460 )

• at birth mice cannot breath

growth/size/body

decreased body weight ( J:63460 )

• mice are 50.3% of wild-type weight

muscle

abnormal muscle morphology ( J:63460 )

• mice exhibit general hypotrophia with particularly underdeveloped intercostals muscles

Allelic Composition	Igf1r^tm1.2Mhz/Igf1r⁺ Zfand2b^tm1Otin/Zfand2b^tm1Otin
Genetic Background	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1.2Mhz mutation (1 available); any Igf1r mutation (88 available)
Zfand2b^tm1Otin mutation (0 available); any Zfand2b mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:233169 )

• mice exhibit normal spleen weight with no significant alterations in hematocrit and WBC, lymphocyte, granulocyte or platelet number in peripheral blood relative to wild-type or single Igf1r^tm1.2Mhz heterozygous controls at 6 and 12 months of age

• normal % and absolute number of LSK+ cells in bone marrow and spleen with no evidence of reticulin fibers (myelofibrosis) in bone marrow at 12 months of age, unlike in Zfand2b^tm1Otin homozygotes

• normal total number of bone marrow cells, with no significant differences in the number of mature myeloid cells or nucleated red cells relative to wild-type or single Igf1r^tm1.2Mhz heterozygous controls

neoplasm

neoplasm ( J:233169 )

N	• mice do NOT develop myeloproliferative neoplasms, unlike Zfand2b^tm1Otin homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24