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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xisttm1Jae
targeted mutation 1, Rudolf Jaenisch
MGI:2386399
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Xisttm1Jae/Xist+ involves: 129S4/SvJae MGI:3719988
ht2
 		Xisttm1Jae/Xisttm2Jae involves: 129S4/SvJae MGI:3772895
ht3
 		Xisttm1Jae/Xisttm2.1Jae involves: 129S4/SvJae MGI:3772897
cx4
 		Tsixtm1Enl/Tsix+
Xisttm1Jae/Xist+ 		involves: 129S4/SvJae MGI:2680291
ot5
 		Xisttm1Jae/Y involves: 129S4/SvJae MGI:3719990


Genotype
MGI:3719988
ht1
Allelic
Composition		 Xisttm1Jae/Xist+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xisttm1Jae mutation (0 available); any Xist mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal dosage compensation, by inactivation of X chromosome ( J:95871 )
• E7.0 embryos exhibit selective inactivation of the wild-type allele instead of the random inactivation observed in wild-type embryos




Genotype
MGI:3772895
ht2
Allelic
Composition		 Xisttm1Jae/Xisttm2Jae
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xisttm1Jae mutation (0 available); any Xist mutation (8 available)
Xisttm2Jae mutation (2 available); any Xist mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:75502 )
• mouse embryonic fibroblasts exhibit normal X chromosome inactivation




Genotype
MGI:3772897
ht3
Allelic
Composition		 Xisttm1Jae/Xisttm2.1Jae
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xisttm1Jae mutation (0 available); any Xist mutation (8 available)
Xisttm2.1Jae mutation (0 available); any Xist mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:75502 )
• mouse embryonic fibroblasts exhibit normal X chromosome inactivation




Genotype
MGI:2680291
cx4
Allelic
Composition		 Tsixtm1Enl/Tsix+
Xisttm1Jae/Xist+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tsixtm1Enl mutation (1 available); any Tsix mutation (57 available)
Xisttm1Jae mutation (0 available); any Xist mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
decreased embryo size ( J:68136 )
• 7 of 13 embryos were significantly smaller than normal at E8.5 and E9.5
• gastrulation was apparently normal however
• remaining embryos were grossly normal in size and morphology

growth/size/body
decreased embryo size ( J:68136 )
• 7 of 13 embryos were significantly smaller than normal at E8.5 and E9.5
• gastrulation was apparently normal however
• remaining embryos were grossly normal in size and morphology




Genotype
MGI:3719990
ot5
Allelic
Composition		 Xisttm1Jae/Y
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xisttm1Jae mutation (0 available); any Xist mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:80117 )
N
• formation of sex bodies and meiotic sex chromosome inactivation in spermatocytes is normal




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory