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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spam1tm1Tba
targeted mutation 1, Tadashi Baba
MGI:2386404
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spam1tm1Tba/Spam1tm1Tba either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * ICR) MGI:2450108
hm2
 		Spam1tm1Tba/Spam1tm1Tba Not Specified MGI:4398731


Genotype
MGI:2450108
hm1
Allelic
Composition		 Spam1tm1Tba/Spam1tm1Tba
Genetic
Background		 either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * ICR)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spam1tm1Tba mutation (1 available); any Spam1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
impaired fertilization ( J:78559 )
• 30% reduction in ability of sperm to fertilize cumulus-intact eggs compared to wild-type
• ability of sperm to fertilize cumulus-free eggs is comparable to wild-type
• hyaluronidase activity of sperm protein extracts reduced by 80% compared to wild-type




Genotype
MGI:4398731
hm2
Allelic
Composition		 Spam1tm1Tba/Spam1tm1Tba
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spam1tm1Tba mutation (1 available); any Spam1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
impaired fertilization ( J:154516 )
• sperm exhibit reduced accessibility to the Zona Pellucida surface
• increased accumulation on the oocyte-cumulus complex surface
abnormal sperm physiology ( J:154516 )
• sperm exhibit reduced accessibility to the Zona Pellucida surface
• increased accumulation on the oocyte-cumulus complex surface.




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory