Phenotypes associated with this allele

• Allele Symbol: Hmga2^tm1Cha
• Allele Name: targeted mutation 1, Kiran Chada
• Allele ID: MGI:2386412
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hmga2^tm1Cha/Hmga2^tm1Cha	involves: 129S7/SvEvBrd	MGI:2654710
ht2	Hmga2^tm1Cha/Hmga2^+	involves: 129S7/SvEvBrd	MGI:3054550
cx3	Hmga2^tm1Cha/Hmga2^+ Lep^ob/Lep^ob	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3834966
cx4	Hmga2^tm1Cha/Hmga2^tm1Cha Lep^ob/Lep^ob	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3834967

Genotype
MGI:2654710

hm1

• Allelic Composition: Hmga2^tm1Cha/Hmga2^tm1Cha
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:126188 )

♂ • mice lack spermatozoa

abnormal spermatogonia morphology ( J:126188 )

♂ • spermatogonia exhibit signs of cellular damage unlike in wild-type mice

male infertility ( J:126188 )

♂

growth/size/body

shortened head ( J:28571 )

decreased birth weight ( J:28571 )

• low birth weight

decreased body weight ( J:28571 , J:61493 )

• adult mice weight 40% of wild-type (J:28571)

• 47% of wild-type (J:61493)

decreased susceptibility to diet-induced obesity ( J:61493 )

craniofacial

shortened head ( J:28571 )

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:61493 )

cellular

azoospermia ( J:126188 )

♂ • mice lack spermatozoa

abnormal spermatogonia morphology ( J:126188 )

♂ • spermatogonia exhibit signs of cellular damage unlike in wild-type mice

Genotype
MGI:3054550

ht2

• Allelic Composition: Hmga2^tm1Cha/Hmga2⁺
• Genetic Background: involves: 129S7/SvEvBrd

growth/size/body

decreased susceptibility to diet-induced obesity ( J:61493 )

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:61493 )

Genotype
MGI:3834966

cx3

• Allelic Composition: Hmga2^tm1Cha/Hmga2⁺; Lep^ob/Lep^ob
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

growth/size/body

decreased body size ( J:61493 )

• mice are smaller than Lep^ob homozygotes

decreased body weight ( J:61493 )

• 72% of Lep^ob homozygotes

Genotype
MGI:3834967

cx4

• Allelic Composition: Hmga2^tm1Cha/Hmga2^tm1Cha; Lep^ob/Lep^ob
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

growth/size/body

abnormal body weight ( J:61493 )

• body weight is 27% of Lep^ob homozygotes and 59% more than in Hmga2^tm1Cha homozygotes

decreased body size ( J:61493 )

• mice are smaller than Lep^ob homozygotes

adipose tissue

abnormal fat pad morphology ( J:61493 )

• fewer fat cells are found in fat pads compared to in Lep^ob homozygotes

decreased inguinal fat pad weight ( J:61493 )

• compared to in Lep^ob homozygotes

decreased mesenteric fat pad weight ( J:61493 )

• compared to in Lep^ob homozygotes