All Phenotypes Myh10<tm2Rsad> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myh10^tm2Rsad
targeted mutation 1, Robert S Adelstein
MGI:2386445

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myh10^tm2Rsad/Myh10^tm2Rsad	involves: 129S4/SvJae	MGI:3052314
hm2	Myh10^tm2Rsad/Myh10^tm2Rsad	involves: 129S4/SvJae * C57BL/6	MGI:3702180
hm3	Myh10^tm2Rsad/Myh10^tm2Rsad	involves: 129S4/SvJae * C57BL/6J	MGI:2672107
ht4	Myh10^tm2Rsad/Myh10⁺	involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6	MGI:7451019
ht5	Myh10^tm1Rsad/Myh10^tm2Rsad	involves: 129S4/SvJae	MGI:3052317
ht6	Myh10^ehc/Myh10^tm2Rsad	involves: 129S4/SvJae * 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J	MGI:6110154
ht7	Myh10^tm2Rsad/Myh10^tm3.1Rsad	involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6	MGI:7451015
ht8	Myh10^tm2Rsad/Myh10^tm4Rsad	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:3702181
ht9	Myh10^tm2Rsad/Myh10^tm5Rsad	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:3702182
cx10	Myh10^tm2Rsad/Myh10^tm2Rsad Myh14^tm1Rsad/Myh14^tm1Rsad	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:4888251

Allelic Composition	Myh10^tm2Rsad/Myh10^tm2Rsad
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10^tm2Rsad mutation (1 available); any Myh10 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

The hydrocephalus seen in Myh10^tm2Rsad/Myh10^tm2Rsad mice is rescued by Myh9 expression in Myh10^{tm6(Myh9/GFP)Rsad}/Myh10^{tm6(Myh9/GFP)Rsad} mice

cardiovascular system

cardiovascular system phenotype ( J:248868 )

N	• epicardial cells exhibit normal migration in vitro in a scratch wound assay

abnormal heart morphology ( J:248868 )

• authors state that mice exhibit similar heart defects as observed in Myh10^ehc homozygotes

abnormal myocardium compact layer morphology ( J:248868 )

• does not display organized clusters of smooth muscle cells or vascular structures unlike wild-type myocardium

abnormal fetal cardiomyocyte morphology ( J:92230 )

• the percentage of binucleated cells is increased to 23% from 1% in wild-type

decreased fetal cardiomyocyte number ( J:92230 )

• at E14.5, the number of cardiac myocytes is reduced by about 70% relative to that in wild-type controls

increased fetal cardiomyocyte size ( J:92230 )

• the size of myocytes is increased at E12.5

absent coronary vessels ( J:248868 )

thin ventricular wall ( J:92230 )

• at E12.5 the number of cell layers in the ventricles is reduced to 2 - 3 compared to 4 - 5 in wild-type hearts

decreased fetal cardiomyocyte proliferation ( J:92230 )

• proliferation of cardiac myocytes is decreased at E14.5

cellular

decreased fetal cardiomyocyte proliferation ( J:92230 )

• proliferation of cardiac myocytes is decreased at E14.5

increased cardiomyocyte apoptosis ( J:248868 )

• in the myocardium at E14.5

• however, there is no statistically significant change in apoptosis in the epicardium or in the heart at E9.5

muscle

abnormal myocardium compact layer morphology ( J:248868 )

• does not display organized clusters of smooth muscle cells or vascular structures unlike wild-type myocardium

decreased fetal cardiomyocyte proliferation ( J:92230 )

• proliferation of cardiac myocytes is decreased at E14.5

increased cardiomyocyte apoptosis ( J:248868 )

• in the myocardium at E14.5

• however, there is no statistically significant change in apoptosis in the epicardium or in the heart at E9.5

nervous system

hydrocephaly ( J:124610 )

abnormal spinal cord morphology ( J:124610 )

• the spinal cord is obstructed in mutants

Allelic Composition	Myh10^tm2Rsad/Myh10^tm2Rsad
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10^tm2Rsad mutation (1 available); any Myh10 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

hydrocephaly ( J:112536 )

• mice show severe hydroencephaly

abnormal fourth ventricle morphology ( J:112536 )

• mice show protrusion of facial neurons into fourth ventricle

cardiovascular system

abnormal cardiac outflow tract development ( J:245570 )

• E14.5 hearts exhibit defects in outflow tract (OFT) alignment

• at E11.5, cardiac myocytes do not invade the underlying cardiac cushions, indicating defective myocardialization of the developing OFT

• at E11.5, cardiac myocytes show abnormal enrichment of N-cadherin at the cell-cell boundaries, indicating defects in the disassembly of cell-cell adhesions

abnormal fetal cardiomyocyte morphology ( J:168304 )

• 13% of cardiomyocytes exhibit an abnormal shape and 15% are binucleated

decreased fetal cardiomyocyte number ( J:168304 )

• at E13.5, hearts exhibit a marked reduction in cardiomyocytes

abnormal atrioventricular valve development ( J:245570 )

• atrioventricular cushions exhibit normal fusion at E12.5 but show a delay in further maturation into mitral and tricuspid valves at E14.5

double outlet right ventricle ( J:245570 )

growth/size/body

growth/size/body region phenotype ( J:245570 )

N	• embryos DO NOT exhibit defects in ventral body wall closure or midline fusion

Allelic Composition	Myh10^tm2Rsad/Myh10^tm2Rsad
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10^tm2Rsad mutation (1 available); any Myh10 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cardiac defects in newborn Myh10^tm2Rsad/Myh10^tm2Rsad mice

mortality/aging

neonatal lethality, complete penetrance ( J:44181 )

• homozygotes that survive to term exhibit congestive heart failure and die during the first postnatal day

prenatal lethality, incomplete penetrance ( J:44181 )

• ~65% of homozygotes die prior to birth

cardiovascular system

liver vascular congestion ( J:44181 )

abnormal fetal cardiomyocyte morphology ( J:44181 )

• newborn hearts show mild to moderate myofibrillar disarray as well as clear areas of cytoplasm corresponding to accumulations of glycogen particles

• right atrial myocytes are enlarged and contain significantly more cisterns of endoplasmic reticulum and Golgi complexes, as well as abundant glycogen particles

fetal cardiomyocyte disarray ( J:44181 )

• newborn hearts show mild to moderate myofibrillar disarray

increased fetal cardiomyocyte size ( J:44181 )

• as early as E12.5, homozygotes exhibit cardiac myocyte hypertrophy throughout the ventricles and atria, as shown by a significant increase in RV+LV cardiomyocyte diameter

• newborn hearts show enlarged right atrial myocytes

overriding aortic valve ( J:44181 )

dilated heart right atrium ( J:44181 )

• newborn homozygotes show right atrial dilatation

perimembraneous ventricular septal defect ( J:44181 )

• 6 of 7 newborn homozygotes exhibit a VSD located beneath the aortic valve; the muscular portion of the ventricular septum remains intact

globular heart ( J:44181 )

• newborn homozygotes display abnormal rounded hearts

abnormal aortic valve morphology ( J:44181 )

• 6 of 7 homozygotes exhibit a rightward malposition of the aortic valve, so that it straddles the ventricular septum and the septal defect or emanates almost entirely from the right ventricle; the defect is found in the membranous portion of the ventricular septum

heart right ventricle outflow tract stenosis ( J:44181 )

• in 6 of 7 newborn homozygotes, the right ventricular outflow tract is narrowed by hypertrophic muscle

congestive heart failure ( J:44181 )

• newborn homozygotes die of congestive heart failure with secondary tissue changes noted in the liver, kidney, and spleen

craniofacial

domed cranium ( J:44181 )

• newborn homozygotes exhibit dome-shaped heads due to hydrocephalus involving the lateral ventricles

liver/biliary system

abnormal liver morphology ( J:44181 )

• newborn homozygotes exhibit a dark purple, congested liver that is visible through the skin

liver vascular congestion ( J:44181 )

nervous system

hydrocephaly ( J:44181 )

• newborn homozygotes display hydrocephalus involving the lateral ventricles

absent retina bipolar cells ( J:44181 )

• newborn homozygotes fail to develop the bipolar layer of retinal ganglion cells

behavior/neurological

abnormal suckling behavior ( J:44181 )

• all moribund pups are unable to nurse

growth/size/body

abnormal birth body size ( J:44181 )

• newborn homozygotes exhibit a variable body size

vision/eye

abnormal retina morphology ( J:44181 )

• newborn homozygotes display retinal dysplasia with rosette formation

absent retina bipolar cells ( J:44181 )

• newborn homozygotes fail to develop the bipolar layer of retinal ganglion cells

skeleton

domed cranium ( J:44181 )

• newborn homozygotes exhibit dome-shaped heads due to hydrocephalus involving the lateral ventricles

Allelic Composition	Myh10^tm2Rsad/Myh10⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10^tm2Rsad mutation (1 available); any Myh10 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:245570 )

N	• embryos DO NOT exhibit defects in ventral body wall closure

Allelic Composition	Myh10^tm1Rsad/Myh10^tm2Rsad
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10^tm1Rsad mutation (1 available); any Myh10 mutation (95 available)
Myh10^tm2Rsad mutation (1 available); any Myh10 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiac hypertrophy ( J:92230 )

• mutants develop postnatal cardiac hypertrophy however at E13.5 no increase in the number of binucleated cardiac myocytes or in the size of cardiac myocytes is seen

growth/size/body

cardiac hypertrophy ( J:92230 )

• mutants develop postnatal cardiac hypertrophy however at E13.5 no increase in the number of binucleated cardiac myocytes or in the size of cardiac myocytes is seen

Allelic Composition	Myh10^ehc/Myh10^tm2Rsad
Genetic Background	involves: 129S4/SvJae * 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10^ehc mutation (0 available); any Myh10 mutation (95 available)
Myh10^tm2Rsad mutation (1 available); any Myh10 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:248868 )

• in late gestation

cardiovascular system

abnormal heart morphology ( J:248868 )

• authors state that mice exhibit similar heart defects as observed in Myh10^ehc homozygotes

abnormal myocardium compact layer morphology ( J:248868 )

• does not display organized clusters of smooth muscle cells or vascular structures unlike wild-type myocardium

absent coronary vessels ( J:248868 )

muscle

abnormal myocardium compact layer morphology ( J:248868 )

• does not display organized clusters of smooth muscle cells or vascular structures unlike wild-type myocardium

Allelic Composition	Myh10^tm2Rsad/Myh10^tm3.1Rsad
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10^tm2Rsad mutation (1 available); any Myh10 mutation (95 available)
Myh10^tm3.1Rsad mutation (1 available); any Myh10 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

failure of ventral body wall closure ( J:245570 )

• embryos exhibit defects in ventral body wall closure

Allelic Composition	Myh10^tm2Rsad/Myh10^tm4Rsad
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10^tm2Rsad mutation (1 available); any Myh10 mutation (95 available)
Myh10^tm4Rsad mutation (1 available); any Myh10 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

hydrocephaly ( J:112536 )

• mice show severe hydroencephaly

abnormal fourth ventricle morphology ( J:112536 )

• mice show protrusion of facial neurons into fourth ventricle

Allelic Composition	Myh10^tm2Rsad/Myh10^tm5Rsad
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10^tm2Rsad mutation (1 available); any Myh10 mutation (95 available)
Myh10^tm5Rsad mutation (0 available); any Myh10 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

hydrocephaly ( J:112536 )

• mice show severe hydroencephaly

abnormal fourth ventricle morphology ( J:112536 )

• mice show protrusion of facial neurons into fourth ventricle

Allelic Composition	Myh10^tm2Rsad/Myh10^tm2Rsad Myh14^tm1Rsad/Myh14^tm1Rsad
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10^tm2Rsad mutation (1 available); any Myh10 mutation (95 available)
Myh14^tm1Rsad mutation (1 available); any Myh14 mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:168304 )

• embryos die as a result of cardiomyopathy after E14.5

cellular

abnormal microtubule cytoskeleton morphology ( J:168304 )

• cardiomyocytes show an increase in acetylated tubulin staining suggesting an increase in microtubule stability

abnormal centrosome morphology ( J:168304 )

• at E13.5, gamma-tubulin staining showed abnormal formation of multiple centrosomes in mitotic cardiac myocytes

abnormal mitosis ( J:168304 )

• cardiomyocytes exhibit impaired karyokinesis and multiple centrosomes

abnormal mitotic spindle morphology ( J:168304 )

• mitotic cardiomyocytes lack a bipolar spindle at metaphase; instead, spindles are deformed with irregular aggregated chromosomes

cardiovascular system

abnormal fetal cardiomyocyte morphology ( J:168304 )

• at E13.5, 91% of cardiomyocytes exhibit an abnormal shape

• 9% of cardiomyocytes are binucleated

• nuclei are irregular and significantly larger, sometimes exhibiting a multilobed appearance

• mitotic cardiomyocytes lack a bipolar spindle; instead, spindles are deformed with irregular aggregated chromosomes

• however, sarcomere formation is normal in E13.5 cardiac myocytes

decreased fetal cardiomyocyte number ( J:168304 )

• at E13.5, hearts exhibit a marked reduction in cardiomyocytes

heart hypoplasia ( J:168304 )

• embryonic heart is severely hypoplastic; however, numbers of cardiac myocytes are sufficient to support life to E14.5

cardiomyopathy ( J:168304 )

muscle

cardiomyopathy ( J:168304 )

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