Analysis Tools
mortality/aging
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• rare, severely affected mice with nearly complete recombination die at 2 - 3 weeks of age
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nervous system
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• some lobules are reduced in size with lobes VI and VII most severely affected and often fused
• in a few rare cases with near complete recombination lobulation is severely aberrant
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• cells are more densely packed at P4 and the layer is thicker at P10
• however, the number of proliferating cells per lobe length is not significantly different from controls
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• cell numbers but not cell density are reduced in the anterior and posterior lobes
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• the dendritic tree is often less elaborate
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• cell numbers but not cell density are reduced in the anterior and posterior lobes
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• contains fewer cells at P4
• however, layer thickness and cell density are similar to controls in adults
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• virtually absent in a few rare cases with near complete recombination
• in less severely affected the vermis is slightly flattened
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• at P4
• in a few rare cases with near complete recombination the cerebellum is severely reduced in size
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behavior/neurological
