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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rfx5tm1Ifo
targeted mutation 1, Irmgard Foerster
MGI:2386499
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rfx5tm1Ifo/Rfx5tm1Ifo involves: 129P2/OlaHsd * C57BL/6J MGI:6513985
cn2
 		Rfx5tm1Ifo/Rfx5tm1.1Ifo
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129 * C57BL/6 * C.B-20 MGI:3844880


Genotype
MGI:6513985
hm1
Allelic
Composition		 Rfx5tm1Ifo/Rfx5tm1Ifo
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rfx5tm1Ifo mutation (1 available); any Rfx5 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:282535 )
N
• NK cells exhibit normal metabolic state




Genotype
MGI:3844880
cn2
Allelic
Composition		 Rfx5tm1Ifo/Rfx5tm1.1Ifo
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129 * C57BL/6 * C.B-20
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Rfx5tm1.1Ifo mutation (0 available); any Rfx5 mutation (34 available)
Rfx5tm1Ifo mutation (1 available); any Rfx5 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal MHC II cell surface expression on macrophages ( J:67924 )
• only 6.2% of bone marrow derived macrophages express MHC-II on the surface compared to 30% of controls
• incubation with IFN-gamma increases percentage to 19% which is much less than 72% of wild-type macrophages

hematopoietic system
abnormal MHC II cell surface expression on macrophages ( J:67924 )
• only 6.2% of bone marrow derived macrophages express MHC-II on the surface compared to 30% of controls
• incubation with IFN-gamma increases percentage to 19% which is much less than 72% of wild-type macrophages




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory